摘要
目的 探讨α-硫辛酸注射液与小牛血清去蛋白注射液联合应用对糖尿病周围神经病变（DPN）患者神经功能、氧化应激及预后的影响。 方法 将94例DPN患者依据治疗方法不同分为两组，每组47例。对照组予以α-硫辛酸注射液治疗，研究组予以α-硫辛酸注射液与小牛血清去蛋白注射液联合治疗。统计两组临床效果，并对比治疗前后正中神经、尺神经、腓神经运动神经传导速度（MCV）、感觉神经传导速度（SCV）、神经病变主觉症状（TSS）评分；出院3个月后随访，比较两组患者治疗前后的生活质量。 结果 与对照组比较，研究组治疗后感觉异常、麻木、疼痛、烧灼感评分均明显较低，差异有统计学意义（P〈0.05）；与对照组比较，研究组治疗后SCV、MCV均较高，差异有统计学意义（P〈0.05）；研究组临床总有效率（95.74%）高于对照组（80.85%），差异有统计学意义（P〈0.05）；两组治疗前躯体功能、心理功能、社会功能、物质生活状态评分比较差异未见统计学意义（P〉0.05）；研究组治疗后各项生活质量水平均高于对照组，差异有统计学意义（P〈0.05）。 结论 α-硫辛酸注射液与小牛血清去蛋白注射液联合应用于DPN治疗中，疗效显著，可有效缓解患者周围神经病变症状，改善其神经功能传导速度，提高生活质量，有利于改善预后。
Objective To investigate the effect of alpha thioctic acid injection and calf serum albumin injection on neurological function, oxidative stress and prognosis in patients with diabetic peripheral neuropathy （DPN）. Methods Ninety- four DPN patients were selected and divided into two groups according to the treatment method, with 47 cases in each group. Patients in the control group were treated with alpha thioctic acid injection, and patients in the study group were treated with alpha thioctic acid injection and calf serum albumin injection. The clinical effects and the scores of motor nerve conduction velocity （MCV）, sensory nerve conduction velocity （SCV）, neuropathy symptoms （TSS） of median nerve, ulnar nerve and peroneal nerve before and after treatment of the two groups were compared. After 3 months of follow-up, the quality of life before and after treatment of the two groups were compared. Results Compared with the control group, the abnormal sensation, numbness, pain, burning sensation scores were significantly lower in the study group after treatment, the differences were significant （P 〈 0. 05）. Compared with the control group, MCV, SCV were higher in the study group after treatment, the differences were significant （P 〈 0. 05 ）. The clinical total effective rates of the study group was 80. 85%, which was higher than that of the control group （95.74%）, the difference was significant （P 〈 0. 05 ）. There was no significant difference in the scores of physical function, mental function, social function or material living condition between the two groups before treatment （P 〉 0. 05 ）. Compared with the control group, the quality of life of the study group after treatment was higher, the difference was significant （P 〈 0.05）. Conclusions The curative effect of alpha thioctic acid injection and calf serum albumin injection combined application on DPN is significant, which can effectively allevi- ate the symptoms of peripheral neuropathy and oxidative stress rea
出处
《中国实用医刊》
2017年第17期24-27,共4页
Chinese Journal of Practical Medicine
