摘要
目的探讨在经体外受精(in vitro fertilization,IVF)或单精子卵母细胞浆内注射(Intracytoplasmic sperm injection,ICSI)-胚胎移植冻融周期(Embryo freezing and thawing cycles,ET)(IVF/ICSI-ET)治疗的单胎及双胎早期妊娠中血清催乳素(prolactin,PRL)的变化趋势及差异,并评估其对先兆流产的预测价值。方法回顾性分析2015年8月至2016年2月在安徽医科大学第一附属医院生殖中心行IVF/ICSI-ET并获得妊娠的妇女281例,根据B超单双胎及有无阴道流血分为:单胎组163例(正常妊娠114例,先兆流产49例),双胎组118例(正常妊娠70例,先兆流产48例),检测各组妊娠前PRL值及妊娠6~9周时PRL值。结果各组在年龄、不孕类型、不孕年限、周期类型、基础血清催乳素等方面差异均无统计学意义(P>0.05),妊娠后PRL值较基础PRL值明显升高,单胎组和双胎组早期妊娠PRL值差异有统计学意义(P<0.05),但单胎正常组与先兆流产组、双胎正常组与先兆流产组之间催乳素值差异均无统计学意义(P>0.05)。结论PRL值在早孕期明显上升,且在双胎妊娠中PRL值上升更显著,但对于判断先兆流产预后价值仍有待进一步研究。
Objective To explore the changes of serum prolactin in first trimester between single and twins pregnancy in vitro fertilization or intracytoplasmic sperm injection embryo transplantation （IVF/ICSI -ET）, and evaluate the predictive value of threatened abortion. Methods 281 cases pregnancy women with IVF/ICSI -ET from August 2015 to February 2016 in the first affiliated hospital of Anhui medical university reproductive center were retrospectively analyzed. They were divided into singleton group （n ~ 163） and twins group （n ~ 118） according to the the B-ultrasonic. Among the singleton group, there were 114 cases normal pregnancy while other 49 cases were with threatened abortion signs. Among the twins group, there were 70 cases normal pregnancy while other 48 cases were with threatened abortion signs. The serum prolactin level before pregnancy 6~9 weeks after pregnancy were tested. Results There was no difference in the age, type of infertility, duration of infertility, cycle type, basic aspects of serum prolactin among each group （P〉0.05）. The serum prolactin levels 6-9 weeks after pregnancy increased significantly than based prolactin levels, and it was higher in twins group compared with singleton group, the difference was statistically significant （P 〈 0.05）. While there was no statistical difference in the prolactin level between normal pregnancy and threatened abortion group （P〉 0.05）. Conclusions Serum prolactin rises obviously in early pregnancy, and the twin pregnancy rises more obvious. The value of serum prolactin in judging the prognosis of threatened abortion needs further research.
出处
《中国妇产科临床杂志》
CSCD
北大核心
2017年第5期428-430,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
国家科技支撑计划(2012BAI32B00)
