摘要
目的:探讨静脉注射乌拉地尔与硝酸甘油微泵对高血压患者拔牙术中血压及心率(HR)的影响。方法:选择自2015年1月到2016年10月在我院进行心电监护拔牙的高血压患者116例纳入本次研究,根据随机数字表法将患者分成观察组以及对照组各58例,对照组给予硝酸甘油加泵静点维持,观察组给予乌拉地尔加泵静点维持,对比两组术前、麻醉时、麻醉后10min、术中及术后10min收缩压(SBP)、舒张压(DBP)以及HR的变化,并对比两组不良反应情况。结果:两组术中及术后10min的SBP和DBP水平均分别明显低于术前,观察组术中的SBP和DBP水平均分别明显低于对照组,差异均有统计学意义(P<0.05);对照组术中及术后10min的HR均明显高于术前,且观察组均明显低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应的总发生率是6.90%(4/58),与对照组的10.34%(6/58)相比,差异无统计学意义(P>0.05)。结论:静脉注射乌拉地尔对高血压患者在拔牙术中血压及HR的影响较小,安全性较好,值得推广。
Objective： To study influence of intravenous injection urapidil and nitroglycerin micro pump on blood pressure and heart rate （HR） of hypertension patients undergoing tooth extraction. Methods： 116 hypertension patients underwent electrocardiographic monitoring tooth extraction in our hospital from January 2015 to October 2016 were enrolled in this study. According to the random number table method,the patients were divided into observation group and control group with 58 cases, the control group was given nitroglycerin plus pump static point to maintain, the observation group was given intravenous urapidil and pump maintenance, compared the changes of systolic blood pressure （SBP）, diastolic blood pressure （DBP） and HR in two groups before operation, at anesthesia, 10min after anesthesia, in operation, 10 min after operation, and compared the adverse reactions condition of the two groups. Results： The levels of SBP and DBP in two groups in operation and 10 min after operation were significantly lower than that before operation, and the SBP and DBP levels in the observation group in operation were significantly lower than control group, the differences were statistically significant （all P〈0.05）. The HR in control group in operation, 10 min after operation were significantly higher than before operation, while the observation group were significantly lower control group, the differences were statistically significant （P〈0.05）. The total incidence of adverse reactions in the observation group was 6.90%（4/58）, which has no significant difference than 10.34% （6/58） in control group （P〉0.05）. Conelusiun： Intravenous injection urapidil has little effect on blood pressure and HR in hypertension patients undergoing tooth extraction, and with good safety, which is worthy of promotion.
出处
《现代生物医学进展》
CAS
2017年第26期5161-5164,共4页
Progress in Modern Biomedicine
基金
沧州市科学技术研究与发展指导计划项目(09ZD286)
关键词
乌拉地尔
硝酸甘油
微泵
高血压
拔牙术
血压
心率
Urapidil
Nitroglycerin
Micro pump
Hypertension
Tooth extraction
Blood pressure
Heart rate
