摘要
目的探讨在体外授精(in-vitro fertilization,IVF)超排卵周期,基础窦卵泡数(basisantral follicle count,b AFC)预测卵巢低反应性的价值。方法收集国内外有关b AFC与IVF超排卵周期卵巢低反应的相关研究,符合纳入与排除标准的相关文献共11篇,涉及患者11425例,采用Rev Man5.2软件对纳入的文献进行meta分析。结果通过对纳入的11项研究进行meta分析显示,b AFC直接影响获卵数和促性腺激素(Gn)使用量(支),b AFC越多,获卵数越多,促性腺激素(Gn)使用量越少,差异有统计学意义。获卵数(SMD合并-0.87,95%CI:-1.22--0.52;Z=4.84,P<0.00001);促性腺激素(Gn)使用量(支)(SMD合并0.68,95%CI:0.21-1.15;Z=2.83,P=0.005)。结论 b AFC对IVF超排卵周期卵巢低反应性具有预测价值,可作为独立监测指标。
Objective To conduct meta-analysis of b AFC prediction of poor ovarian response to ovarian hyperstimulation during IVF cycles. Methods According to inclusion and exclusion criteria,data on related studies of antral follicle count and poor ovarian response was collected via electronic databases. A total of eleven pieces of literature involving 11425 patients were included and metaanalysis was made with Rev Man5. 2 software. Results Eleven studies were included in the meta-analysis. The results showed that along with the increase of b AFC,the number of oocytes obtained became larger. b AFC had a direct effect on the number of oocytes retrieved and the amount of gonadotropin（ Gn） used. Conclusions Meta-analysis suggests that b AFC can serve both as a predictor of poor ovarian response to ovarian hyperstimulation during IVF cycles and as an independent indicator of surveillance.
出处
《武警医学》
CAS
2017年第8期784-788,共5页
Medical Journal of the Chinese People's Armed Police Force
关键词
基础窦卵泡数
卵巢低反应性
体外授精
META分析
baseline antral follicle count
ovarian reaction
in-vitro fertilization
meta-analysis
