摘要
目的:通过弥散张量成像和纤维束密度成像探讨老年抑郁症患者脑白质的完整性。方法:25例老年抑郁症患者为实验组,20名健康老年人为对照组,进行3.0T磁共振弥散张量成像(DTI)和纤维束密度成像(track-density imaging,TDI),并计算其双侧额叶、双侧颞叶、双侧扣带回及胼胝体膝部、压部白质的各向异性分数(FA)和纤维束密度值(track density,TD),分别比较两组数据差异。结果:与对照组相比,实验组左侧额叶、左侧颞叶、双侧扣带回前部及胼胝体膝部FA值显著降低(P<0.05),双侧额叶、双侧颞叶、双侧扣带回前部及胼胝体膝部纤维束密度值显著降低(P<0.05)。结论:老年抑郁症患者多发脑区白质完整性破坏,TDI为高分辨率成像技术,可以清晰显示解剖结构,纤维束密度值可能较各向异性分数更敏感的发现老年抑郁症患者的脑白质异常。
Purpose： To explore the white matter integrity of the patients with late-life depression by using diffusion tensor imaging and track-density imaging. Methods： Twenty-five patients with late-life depression as the experimental group and twenty healthy elders as the control group were enrolled. All the participants were scanned by a 3.0 Tesla scanner to acquire diffusion tensor imaging and track-density imaging. The fractional anisotropy （FA） and track density （TD） were measured in the white matter of the bilateral frontal lobe, temporal lobe, anterior cingulate, the genu and splenium of the corpus callosum. The data were compared between the two groups respectively. Results： Compared with the control group, the experimental group showed significantly decreased FA in the white matter of left frontal lobe, left temporal lobe, bilateral anterior cingnlate, and the genu of corpus callosum（P〈0.05）, and also showed significantly decreased track density in bilateral frontal lobe, bilateral temporal lobe, bilateral anterior cingulate white matter, and the genu of corpus eallosum（P〈0.05）. Conclusion： Late-life depression patients might have disruptions of white matter integrity in multiple brain areas. Track-density imaging is a super-resolution imaging technique, which can be used to clearly display the anatomical structure. Track density may be more sensitive than FA to find the abnormality in the white matter of patients with late-life depression.
出处
《中国医学计算机成像杂志》
CSCD
北大核心
2017年第4期308-313,共6页
Chinese Computed Medical Imaging
基金
国家自然科学基金No.81471656
上海市自然基金NO.14ZR1432100
上海市人才发展基金NO.201555~~
关键词
老年抑郁症
弥散张量成像
纤维束密度成像
各向异性分数
Late-life depression
Diffusion tensor imaging
Track-density imaging
Fractional anisotropy
