摘要
Objective： To observe the clinical efficacy of electroacupuncture（EA） on Alzheimer＇s disease（AD）.Methods： A total of 50 AD patients were randomly allocated into a Western medication（WM） group（n=25） and an acupuncture plus medication（APM） group（n=25）. Patients in the WM group took oral huperzine A capsules. In addition to huperzine A capsules, patients in the APM group also received EA at Shenting（GV 24）, Baihui（GV 20）, Dazhui（GV 14）,Fengfu（GV 16）, Mingmen（GV 4） and Yongquan（KI 1）. The needles on the above points were connected to G6805-Ⅱelectric stimulator [3 pairs： Shenting（GV 24） and Baihui（GV 20）; Dazhui（GV 14） and Fengfu（GV 16）; and bilateral Yongquan（KI 1）]. The needles were retained 25 min. The treatment was done once a day, and 10 times made up a course of treatment.The patients received a total of 3 treatment courses. There was a 3-day interval between two courses. The mini-mental state examination（MMSE） and Hasegawa dementia scale revised（HDS-R） were conducted before and after treatment. The clinical efficacies were evaluated when the treatment was completed.Results： Before treatment, there were no between-group statistical differences in MMSE and HDS-R scores（both P〈0.05）.After treatment, the MMSE and HDS-R scores in the APM group were significantly higher than those in the WM group（both P〈0.05）. The total effective rate in the APM group was 88.0%, versus 76.0% in the WM group, showing a statistical difference（P〈0.05）.Conclusion： EA is effective for AD and can improve clinical symptoms in AD patients.
目的:观察电针治疗阿尔茨海默病(AD)的临床疗效,探讨其临床应用价值。方法:将50例AD患者采用随机数字表分为2组,每组25例。西药组口服石杉碱甲胶囊;针药组在口服石杉碱甲胶囊基础上加用电针治疗,穴位选神庭、百会、大椎、风府、命门和涌泉,针刺得气后接G6805-Ⅱ型电针治疗仪(神庭与百会为一组,大椎和风府为一组,双侧涌泉为一组)。刺激量以患者能够耐受为度。每次留针25 min,每日1次,连续10次为1疗程,两个疗程间休息3 d,共治疗3个疗程。治疗前后进行简易精神状态检查量表(MMSE)和修订后的长谷川智能量表(HDS-R)评分,并于治疗结束后进行临床疗效评价。结果:治疗前两组MMSE及HDS-R评分均无统计学差异(均P>0.05)。治疗后针药组MMSE和HDS-R评分均明显高于西药组(均P<0.05)。治疗后针药组总有效率为88.0%,西药组为76.0%,针药组的临床疗效优于西药组(P<00.05)。结论:电针是治疗AD的有效方法,能有效改善AD患者的临床症状,提高疗效。
基金
supported by Key Research Project of Science and Technology Bureau of Leshan Town,No.15ZDYJ0150~~
