摘要
通过改变盐酸头孢吡肟和L-精氨酸的摩尔比,采用共沉淀的方法制备出了一系列组合物,利用高效液相色谱(HPLC)、红外光谱(IR)和X射线粉末衍射(XRPD)等技术对产品的组成及结晶情况进行了研究,结果显示:在采用共沉淀方法制备的组合物中,盐酸头孢吡肟和精氨酸的摩尔比与投料的摩尔比基本相同,即得到的共沉淀产品为固体溶液,而不是共晶。均一度测试表明,以各种投料比制备的产品均匀性均优于市售物理混合产品。
By changing the mole ratios of Cefepime hydrochloride and L-Arginine, using the coprecipita- tion method, it prepares a series of compositions. The composition and the crystal mophology of were stud- ied by High Performance Liquid Chromatography （HPLC）, Infrared spectroscopy （IR）, X-Ray Power Diffraction （XRPD）. The results showed that mole ratios of Cefepime hydrochloride and L-arginine in the coprecipitation product were the same as the feeding molar ratio, which declared that coprecipitation prod- uct were solid solution, rather than cocrystal. It turned out that the uniformity of the coprecipitation prod- uct was higher than that of the commercial product.
出处
《黄河水利职业技术学院学报》
2017年第3期51-54,共4页
Journal of Yellow River Conservancy Technical Institute
关键词
盐酸头孢吡肟
精氨酸
共沉淀
溶剂体系
Cefepime hydrochloride
L-arginine
eoprecipitation
solvent system
