摘要
目的 观察成人Still病的特征性皮疹及其典型组织病理改变，为成人Still病的早期诊断及治疗提供帮助。方法 分析8例成人Still病患者的临床资料。结果 病程中，8例患者均有一过性皮疹及持久性丘疹/斑块改变，1/8例患者具有荨麻疹样皮疹，3/8例患者具有皮肌炎样皮疹，1/8例患者具有色素性痒疹样皮疹。8例患者皮损组织病理取材于一过性皮疹和（或）持久性丘疹/斑块，病理结果均表现为棘层上部坏死角质形成细胞，真皮浅层血管周围中性粒细胞、淋巴细胞浸润。结论 成人Still病皮疹改变及组织病理改变具有一定特征，可为疾病的早期诊断提供线索。
Objective To investigate characteristic skin lesions and typical histopathological changes of adult-onset Still′s disease（AOSD） for its early diagnosis and treatment. Methods Clinical data were collected from 8 patients with AOSD, and analyzed retrospectively. Results All the patients had transient rashes and persistent papules/plaques during the course of disease. Of the 8 patients, 1 had urticaria-like rashes, 3 had dermatomyositis-like rashes, and 1 had prurigo pigmentosa-like rashes. Biopsies were carried out at the sites where transient rashes or persistent papules/plaques occurred. Histopatho-logical findings showed necrotic keratinocytes in the upper prickle cell layer, and perivascular infiltration of neutrophils and lymphocytes in the upper dermis. Conclusion The skin lesions and histopathological changes of AOSD are characteristic, which can provide clues to the early diagnosis of AOSD.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2017年第9期654-657,共4页
Chinese Journal of Dermatology
基金
吉林省卫生厅科技计划项目（20122092）
关键词
Still病
成年型
皮肤表现
病理学
临床
诊断
Still＇s disease, adult-onset
Skin manifestations
Pathology, clinical
Diagnosis
