摘要
系统性红斑狼疮(SLE)是一种临床常见的累及多系统、多脏器的高异质性自身免疫性疾病,该病以自身抗体产生和免疫复合物沉积为主要病理特征,是因自噬功能异常导致凋亡的累积,诱导自身抗体产生,从而引起的免疫性疾病。自噬的异常在SLE发病的遗传因素、环境因素及免疫因素中均有重要作用,其特异性免疫涉及死亡细胞、细胞内DNA和RNA的清除,Ⅰ型干扰素反应的调节,B细胞和T细胞长期存活调控等。以自噬为靶点对SLE进行干预和治疗尚在研究之中。
Systemic lupus erythematosus （SLE） is a common and multi-system, multiple-organ heterozygous autoimmune disease, the main pathological features of the disease are autoantibody production and immune complex deposition, because autophagy functional abnormalities lead to the accumulation of apoptosis, and induce autoantibodies, resulting in immune disorders. Autophagy abnormalities play an important role on the level of genetic factors, environmental factors and immune factors of SLE. The specific immunity involves the removal of dead cells, intracellular DNA and RNA,regulation of type I interferon, and long-term survival regulation of B cells and T ceils. Intervehtion and treatment of SLE with autophagy as target is still under investigation.
出处
《医学综述》
2017年第17期3363-3367,共5页
Medical Recapitulate
基金
重庆市中医药科技项目(ZY201702010)
关键词
系统性红斑狼疮
自噬
B细胞
Systemic lupus erythematosus
Autophagy
B cell
