摘要
目的分析妊娠期肝内胆汁淤积症导致早产的原因。方法回顾性分析我院2014年1月-2017年1月间收治的114例妊娠期肝内胆汁淤积症孕产妇,对其临床资料进行统计,并结合国内外文献报道,分析妊娠期肝内胆汁淤积症导致早产的原因。结果研究期间我院产科共接收7231例分娩,其中ICP患者共114例1.6%,ICP围产儿中共有24例23.5%早产儿;产妇年龄(以35岁为分界点)、产次、皮肤是否瘙痒以及是否合并糖尿病与ICP围产儿发生早产在统计学上没有关联性,而发病时间(以孕34w为分界点)、是否合并高血压以及ICP的分度与ICP围产儿发生早产在统计学上有关联性;发病时间<孕34w、合并高血压以及重度ICP三者回归系数均为正数,且OR值大于1,这表明发病时间<孕34w、合并高血压以及重度ICP是ICP围产儿发生早产的高危因素。结论妊娠期肝内胆汁淤积症致围产儿早产的高危因素为发病时间<孕34w、合并高血压以及重度ICP,临床上若发现有此指证,应引起重视。
Objective：Analysis of the causes of premature delivery in intrahepatic cholestasis of pregnancy. Methods：Analysis of our hospital in January 2014 January-2017 between 114 cases of intrahepatic cholestasis of pregnancy pregnant women,analysis of intrahepatic pregnancy disorders cause the causes of premature births is expected. Results：During the study period in our hospital received a total of 7231 cases of delivery,including a total of 114 ICP patients were ICP（1.6%）,a total of 24 cases of perinatal infants（23.5%）;maternal age（35 years as the cut-off point）,parity,skin itching and whether diabetes mellitus and perinatal ICP occur early yield no relevance in statistics,the onset time（at 34 weeks of pregnancy as the cut-off point）,and whether hypertension grading and ICP ICP perinatal premature birth have relevance in statistics;the onset time of 34 weeks of gestation hypertension and severe ICP three regression coefficients were positive,and the OR value is greater than 1,the that time is less than 34 weeks of gestation,the incidence of hypertension and severe ICP ICP perinatal risk factors of preterm birth. Conclusion ：The high risk factors of perinatal premature delivery in pregnant women with intrahepatic cholestasis of pregnancy are the onset time of 34 weeks of pregnancy,hypertension,and severe ICP.
出处
《中国优生与遗传杂志》
2017年第8期83-84,128,共3页
Chinese Journal of Birth Health & Heredity
关键词
妊娠期肝内胆汁淤积症
早产
原因分析
Intrahepatic cholestasis of pregnancy
Premature delivery
Reason analysis
