摘要
目的比较晚期结直肠癌联合化疗后使用国产和进口卡培他滨维持治疗的临床效果及安全性。方法将47例晚期结直肠癌患者随机分为进口组(26例)和国产组(21例),两组分别使用进口和国产卡培他滨片,每天2.5 g/m2,连用14 d,服用14 d后停药7 d,21 d为1个周期。观察两组维持治疗无进展生存期、生活质量及不良反应。结果两组无进展生存期、生活质量改善情况、不良反应发生率比较,差异均无统计学意义(P>0.05)。结论晚期结直肠癌联合化疗后使用国产卡培他滨片维持治疗与进口卡培他滨片相比同样安全有效。
Objective To compare the clinical efficacy and safety of maintenance therapy with imported and domestic capecitabine after chemotherapy in patients with incurable colorectal cancer. Methods Forty - seven patients with incurable colorectal cancer were divided into imported group （26 cases） and domestic group （21 cases）. The two groups were treated with imported and domestic capecitabine respectively, 2. 5 g/m2 daily, dI N dl4 , 21 days were one cycle. The progression - free - sur- vival （ PFS ） , the changes on quality of life （ QOL ） , and the adverse reactions were observed after maintenance therapy. Results The median PFS, the ratio of improvement and stability in the changes on quality of life （QOL） and the main adverse reactions between the two groups had no significant difference （ P 〈 0. 05 ）. Conclusion It is safe and effective for domestic capecitabine equally compared with imported capecitabine in the treatment of incurable colorectal cancer.
出处
《河南医学研究》
CAS
2017年第17期3080-3082,共3页
Henan Medical Research
关键词
卡培他滨
晚期结直肠癌
维持治疗
capecitabine
incurable colorectal cancer
maintenance therapy
