摘要
目的:探讨柴胡疏肝散联合西酞普兰对抑郁症患者血清锌水平、认知功能及临床疗效的影响。方法:收集我院就诊或住院治疗的80例抑郁症患者,随机分为实验组和对照组,每组40例。对照组患者给予西酞普兰20 mg/d,2次/d。根据病人的耐药情况,1周后增至40 mg/d,2次/d。实验组患者在对照组基础上给予柴胡疏肝散,每日1剂,早晚分服。治疗均连续4周。治疗结束后,对患者的血清Zn水平、韦氏记忆量表(WMS-RC)评分、汉密尔顿焦虑量表(HAMD)评分以及患者的临床疗效进行检测并比较。结果:与治疗前相比,两组患者的血清Zn水平、长时记忆、短时记忆以及记忆商数评分均升高(P<0.05),HAMD评分水平下降(P<0.05);与对照组相比,实验组患者的血清Zn水平、长时记忆、短时记忆以及记忆商数评分较高(P<0.05),HAMD评分水平较低(P<0.05),临床治疗总有效率较高(P<0.05);两组患者的即刻记忆评分无差异(P>0.05)。结论:柴胡疏肝散联合西酞普兰能够升高抑郁症患者血清锌水平,改善患者认知功能,临床疗效较好。
Objective：To investigate Chaihu Shugan Powder combined with citalopram on serum zinc levels in patients with depression, the effect of cognitive function and clinical outcomes. Methods ： 80 cases of depression patients from our hospital were selected and randomly divided into experimental group and control group, with 40 cases in each group. The control group were treated with citalopram 20 mg/d,2 times/d. According to the patients＇ drug resistance, 1 weeks after the increase to 40 mg/d,2 times/d. The patients in the experimental group were given Chaihu Shugan Powder group based on the 1 day, sooner or later. Treatment for 4 consecutive weeks. After the end of treatment and on the patients＇ serum Zn level, Wechster Memory Quantity Scale （ WMS-RC ） score, Hamilton Anxiety Rating Scale （ HAMD ） and in patients with clinical efficacy were detected and compared. Results： Compared with before treatment, two groups of patients with serum Zn level, long memory, short-term memory and memory quotient scores were increased （ P〈0.05 ）, HAMD score level was decreased （ P〈0.05 ）; compared with the control group, the serum levels of Zn, long short term memory and write memory and memory quotient scores were higher （ P〈0.05 ）, the HAMD scores level was lower（ P〈0.05 ）,the clinical treatment and total effective rate were higher（ P〈0.05 ）; two groups of patients with immediate memory score had no difference （ P〉0.05 ）. Conclusion ： Chaihu Shugan Powder combined with citalopram could increase serum Zn levels in patients with depression, improve the cognitive function of patients, the clinical curative effect is satisfactory.
出处
《辽宁中医药大学学报》
CAS
2017年第8期199-201,共3页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
柴胡疏肝散
西酞普兰
抑郁症
ZN
认知功能
Chaihu Shugan Powder
citalopram
depression
Zn
cognitive function
