摘要
环境致癌因子攻击DNA等生物大分子造成DNA原始损伤,成为细胞癌变的起始动力。但机体存在的DNA损伤修复系统对于维持基因组的稳定性具有重要意义。DNA修复基因作为首类环境应答基因,其遗传多态性一直是恶性肿瘤易感及预后生物标志研究的热点。然而近年来研究发现基于碱基序列改变的单核昔酸多态性及单体型显然不足以全面反映转录组和蛋白质组多态性,而表观遗传学RNA调控领域的研究进展却拓宽了相应的研究思路。DNA修复基因可变剪接及非编码RNA调控网络作为恶性肿瘤发生及预后生物学标志的研究及意义备受关注。本研究对体现蛋白质多样性及疾病表达复杂性的可变剪接及包括microRNA、lncRNA、circRNA在内的非编码RNA调控网络调控DNA修复基因的作用及其在环境致癌因子所致恶性肿瘤发生发展中的生物学意义进行简要综述。
DNA damage induced by environmental carcinogens is commonly considered the original motive of chemical carcinogenesis. There is several DNA repair systems to maintain genomic stability in cells. DNA repair gene is known as the first environmental response gene, whose genetic polymorphism is considered as the important biomarker to predict the susceptibility and prognosis of cancer. However single nucleotide polymorphism （SNP） can＇t totally reflect the diversity of protein or transcriptome, the alternative splicing and non-coding RNA network related to DNA repair genes attract much more attention due to its significant value in the occurrence and development of cancer. Our review is focused on the effect of alternative splicing and non-coding RNA regulation on the development of cancer and the significance as a critical biomarker to predict the susceptibility and prognosis of cancer.
出处
《沈阳医学院学报》
2017年第4期301-305,309,共6页
Journal of Shenyang Medical College
基金
国家自然基金项目(No.81273118
No.30972506)
