摘要
目的探讨前列地尔联合常规治疗对老年2型糖尿病(T2DM)合并慢性肾脏病(CKD)患者的治疗效果。方法人选2014年2月至2016年2月在攀枝花市中心医院内分泌科治疗的90例老年T2DM合并CKD患者,采用数字表法随机分为前列地尔组和对照组,每组45例。对照组给予常规治疗,前列地尔组在常规治疗基础上加用前列地尔10μg/d,静脉推注,1次/d,2周为1个疗程,共治疗3个疗程。比较两组患者血脂、血糖、肝功能、肾功能等指标。所有数据采用SPSS 16.0软件进行统计学分析。计量资料用均数±标准差(±s)表示,两组比较采用t检验。计数资料用百分率表示,组间比较用χ~2检验。结果两组患者治疗前空腹血糖(FPG)、糖化血红蛋白(HbAlc)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、同型半胱氨酸(Hcy)、血β2微球蛋白(β2-MG)、尿白蛋白排泄率(UAER)、血肌酐(SCr)、估算肾小球滤过率(eGFR)差异均无统计学意义(P>0.05)。治疗后,前列地尔组患者的TG、TC、LDL-C、Hcy、β2-MG、UAER显著低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗前后的凝血酶原时间(PT)、血小板(PLT)、活化部分凝血活酶时间(APTT)差异无统计学意义(P>0.05)。两组不良反应发生率差异无统计学意义(χ~2=0.212,P=0.645)。结论前列地尔联合常规治疗能显著降低老年T2DM合并CKD患者尿蛋白水平,对患者的肾功能具有一定的保护作用。
Objective To investigate the efficiency of alprostadil combined with conventional therapy on elderly type 2 diabetes mellitus （T2DM） patients complicated with chronic kidney disease （CKD）.Methods A total of 90 elderly T2DM patients with CKD admitted in our hospital from February 2014 to February 2016 were recruited in this study.They were randomly divided into alprostadil group and control group （n=45）.Conventional basic treatment was given to the patients of the 2 groups,and 10 μg/d alprostadil （once per day） was given to the alprostadil group by intravenous injection with 2 weeks as a course,for totally 3 courses.The indices of blood lipids,blood glucose,liver function and renal function were compared between the 2 groups.SPSS statistics 17.0 was used to analyze the data.The measurement data were expressed as mean±standard deviation （±s）,and Student＆#39;s t test was employed for the comparison between groups.Enumeration data were expressed as percentage,and inter-group comparison was carried out with Chi-square test.Results There were no significant differences in fasting plasma glucose （FPG）,glycosylated hemoglobin A1c （HbA1c）,triglycerides （TG）,total cholesterol （TC）,high-density lipoprotein cholesterol （HDL-C）,low-density lipoprotein cholesterol （LDL-C）,homocysteine （Hcy）,blood β2-microglobulin （β2-MG）,serum creatinine （SCr）,and urinary albumin excretion rate （UAER） and estimated glomerular filtration rate （eGFR） between the 2 groups before treatment （P〉0.05）.After the treatment,the levels of TG,TC,LDL-C,Hcy and β2-MG and UAER were significantly lower in the alprostadil group than in the control group （P〈0.05）.No significant differences were observed in prothrombin time （PT）,platelet （PLT） count,and activated partial thromboplastin time （APTT） between the 2 groups before and after treatment （P〉0.05）.There were no any differences in the incidences of adverse reaction （Chi-square=0.212,P=0.645）.Conclusion
出处
《中华老年多器官疾病杂志》
2017年第8期604-608,共5页
Chinese Journal of Multiple Organ Diseases in the Elderly
关键词
老年人
前列地尔
糖尿病2型
慢性肾脏病
aged
alprostadil
type 2 diabetes mellitus
chronic kidney disease
