摘要
目的探讨单用兰索拉唑和兰索拉唑与莫沙必利联合治疗食管反流的疗效及安全性。方法食管反流患者76例,随机分为对照组及观察组,各38例。两组患者均给予兰索拉唑,观察组在此基础上加用莫沙必利。观察患者食管功能、胃电节律情况。应用SPSS 18.0软件,所获数据采用方差分析、t检验。结果对照组治疗前后食管括约肌压力、食管括约肌松弛率、蠕动性收缩比变化比较,P<0.0005。观察组治疗前后食管括约肌压力、食管括约肌松弛率、蠕动性收缩比变化比较,P<0.0005。两组治疗后食管括约肌压力、蠕动性收缩比变化比较,P<0.0005;两组治疗后食管括约肌松弛率变化比较,P<0.05。对照组治疗前后主频率、幅值餐前餐后变化比较,P<0.0005。观察组治疗前后主频率、幅值餐前餐后变化比较,P<0.0005。两组治疗后主频率、幅值餐前餐后变化比较,P<0.0005。结论单用兰索拉唑和兰索拉唑与莫沙必利联合治疗食管反流,两组食管功能均有明显改善,两组胃电节律水平均有明显提高,联合用药明显优于单纯用药。
Objective To investigate the efficacy and safety of single-use lansollozazole and lansolazole combined with moshazole in the treatment of esophageal reflux. Methods 76 cases of esophageal reflux were randomly divided into control group and observation group, 38 cases. The two groups of patients were given lansorazole, and the observation group was based on the use of moxaballi. Observe the patient＇s esophageal function and gastric electrical rhythm. Using SPSS 18.0 software, the data were obtained using variance analysis and t test. Results The control group was treated with sphincter and sphincter, the sphincter of the esophageal sphincter, and the peristaltic contraction ratio compared to the change of peristaltic contractions, P〈0.0005. In the observation group, the pressure of the esophageal sphincter, the relaxation ratio of the esophageal sphincter and the change of peristaltic contractions were compared with the comparison of the changes of the esophageal sphincter, P〈0.0005. After treatment, the pressure of the esophageal sphincter and the peristaltic contraction ratio were compared with the change of the esophageal sphincter, P〈0.0005. The relaxation rate of the esopha- geal sphincter after treatment was compared with P〈0.05. The control group was compared with the main frequency before and after the meal before and after meal, P〈0.0005. Comparison of main frequency before and after the treatment of pre- prandial meal before and after treatment, P〈0.0005. After the two groups were treated, the main frequency and amplitude of the premeal were compared, P〈0.0005. Conclusion Alone with sora azole and LAN sora azole moser will the combination therapy of esophageal reflux, esophageal function were improved significantly in both groups, two groups of gastric electric rhythm level were improved obviously, combination is superior to pure drugs.
出处
《菏泽医学专科学校学报》
2017年第3期57-59,共3页
Journal of Heze Medical College
