摘要
目的探讨宫颈癌放化疗前预置输尿管支架管(双J管)对肾脏的保护作用。方法 158例宫颈癌患者,随机分为试验组和对照组,各79例。试验组患者均在放化疗前预留双J管,对照组患者均未预留。比较两组患者随访至3年后肾积液发生率、血肌酐、肾小球滤过率(GFR)及生存率。结果在随访终点,试验组和对照组分别出现4例和6例患者死亡。试验组患者肾积液、肾功能受损发生率及血肌酐均显著低于对照组,双侧GFR显著高于对照组,差异均具有统计学意义(P<0.01)。试验组3年总生存率为94.7%,与对照组的91.8%比较,差异无统计学意义(P>0.05)。在随访期间未发现置管严重不良反应。结论在宫颈癌患者放化疗前预置双J管对肾脏有显著的保护作用,该方法简便、安全,临床应用价值高,其对宫颈癌远期生存率的影响仍需进一步探究。
Objective To investigate the protective effect of pre-plaeing ureteral stent （double-J stent） on kidney before radiochemotherapy of cervical cancer. Methods A total of 158 cervical cancer patients were randomly divided into experimental group and control group, with 79 cases in each group. The experimental group had pre-placing double J stent before radiochemotherapy, and the control group did not. Comparison were made on incidence of hydronephrosis, serum creatinine, glomerular filtration rate （GFR） and survival rate after 3 years of follow-up in two groups. Results At the end of follow-up, the experimental group and control group respectively had 4 and 6 death cases. The experimental group had significantly lower incidence of hydronephrosis and impaired renal function and serum creatinine than the control group, and significantly higher bilateral GFR than the control group. Their difference had statistical significance （P〈0.01）. The experimental group had no statistically significant difference in 3 year total survival rate as 94.7%, comparing with 91.8% in the control group （P〉0.05）. No severe adverse effects occurred during follow-up. Conclusion Pre-placing double J stent before radiochemotherapy shows remarkable effect for cervical cancer patients, and it is simple and safe with high clinical application value, its impact on the long-term survival rate of cervical cancer still need further study.
出处
《中国实用医药》
2017年第20期1-3,共3页
China Practical Medicine
关键词
输尿管支架管
肾功能
放化疗
宫颈癌
Ureteral stent
Renal function
Radiochemotherapy
Cervical cancer
