摘要
目的探讨改良胸膜纤维板剥脱手术对老年结核性脓胸患者的治疗效果。方法收集2014年3月至2015年6月在陕西省结核病防治院外科接受治疗,年龄≥65岁的85例结核性脓胸患者的临床资料,根据治疗方法分为传统手术组(40例)和改良手术组(45例),其中传统手术组采用常规手术方式进行治疗,改良手术组在常规手术方式的基础上于术中游离肺叶裂,扩大肺裂间隙。观察两组患者的手术情况,比较两组患者的治疗效果、炎症细胞因子[白细胞介素-12(IL-12)、肿瘤坏死因子-α(TNF-α)和C反应蛋白(CRP)]变化情况、肺功能[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)和第1秒用力呼气容积与用力肺活量比值(FEV1/FVC)]恢复情况和并发症发生情况。结果改良手术组的手术时间[(109.76±9.14)min]长于传统手术组[(82.93±8.04)min],住院时间[(14.42±2.42)d]短于传统手术组[(18.37±3.12)d],术中出血量[(235.85±18.22)ml]多于传统手术组[(172.46±15.37)ml],差异均有统计学意义(t值分别为-14.29、6.46、-17.22,P值均〈0.01);改良手术组治疗6个月有效率(97.78%,44/45)明显高于传统手术组(82.50%,33/40),差异有统计学意义(x^2=5.80,P=0.016);治疗后,改良手术组患者的IL-12[(8.68±0.43)pg/ml]、TNF-α[(8.22±2.06)pg/ml]和CRPE(22.2618.45)mg/L5水平均明显低于传统手术组患者[分别为(11.92±0.54)pg/ml、(14.25±2.25)pg/ml和(28.17±11.63)mg/L],差异均有统计学意义(t值分别为30.75、12.90、2.70,P值均〈0.01);改良手术组患者的FVC[2.32±0.65)L]、FEV,U2.13±0.52)L]和FEV1/FVCE(48.26±8.26)%]水平均明显高于传统手术组[分别为(1.83±0.48)L、(1.68±0.34)L和(43.45±6.85)%](t值分别�
Objective To explore the clinical effect of modified decortication of pleural fibreboard on elderly patients with tuberculous empyema. Methods The clinical data of patients with tuberculous empyema who aged ≥65 years and treated in the Department of Surgery, Shaanxi Provincial Tuberculosis Control Hospital from March 2014 to June 2015 were collected. According to the treatment method, patients were divided into traditional surgery group (40 cases) and modified operation group (45 cases). Traditional operation group was operated by routine method; while in the modified operation group, pulmonary lobes were freed and the gap was enlarged. The treatment effect, the levels of cytokines (IL-12, TNF-α and CRP), lung function (FVC, FEV1, and FEV1/FVC) and complication rate were compared between the two groups. Results The operation time of the modified group (( 109.76 ± 9.14) rain) was longer than the traditional surgery group ((82.93 ± 8. 04) rain), the hospitalization time ((14.42±2.42) d) was shorter than traditional surgery group ((18.37 ± 3.12) d), and the level of peroperative bleeding ((235.85±18.22) ml) was higher than traditional surgery group ((172.46± 15.37) ml); the differences were statistically significant (t = - 14.29, 6.46, - 17.22, respectively, all P〈0.01). The treatment efficiency (97. 78%, 44/45) of the modified group was significantly higher than that of the traditional surgery group (82. 50%, 33/40); the difference was statistically significant (x^2 =5.80, P=0. 016). Six months after surgery, patients in the modified group had lower levels of IL-12 ((8.68±0.43) pg/ml), TNF-α ((8. 22±2.06) pg/ml) and CRP ((22.26±8.45) mg/L) compared with the traditional surgery group (IL-12, (11.92±0.54) pg/ml; TNF-α, (14.25±2.25) pg/ml; CRP, (28.17±11.63) mg/L; t=30. 75, 12.90, 2.70, respectively, all P〈0.01). In the modified group, FVC ((2.32±0.65) L), FEV1 ((2.1
出处
《中国防痨杂志》
CAS
2017年第8期857-861,共5页
Chinese Journal of Antituberculosis
基金
陕西省科学技术研究发展计划项目(2012K16-12-05)
关键词
脓胸
结核性
外科手术
诊断技术和方法
治疗结果
评价研究
Empyema, tuberculous
Surgical procedures, operative
Diagnostic techniques and proce- dures
Treatment outcome
Evaluation studies