摘要
目的:系统评价中医化痰法治疗非小细胞肺癌的临床疗效。方法:采用计算机检索CNKI,WANFANG Data,VIP,Pub Med数据库2000年以来公开发表的有关中医化痰法治疗非小细胞肺癌的随机对照试验,实验组中医化痰法加化疗治疗324例,对照组化疗治疗323例,按照纳入和排除标准筛选,对文献进行质量评价,采用STATA11.0统计软件进行对纳入的实验结果的统计学分析。结果:共纳入647例非小细胞肺癌病人,其中实验组324例,对照组323例。中医化痰法治疗后,有效率提高,结果显示相对危险度(RR)=1.48,95%可信区间(95%CI)=1.24~1.77,P<0.001;生活质量改善,结果显示RR=1.92,95%CI=1.51~2.45,P<0.001;可提升免疫力,结果显示均值差MD=0.36,95%CI=0.23~0.50,P<0.001。结论:中医化痰法治疗非小细胞肺癌相比于常规用药疗效更好。
AIM： To systematically evaluate the efficacy of reducing phlegm with traditional Chinese medicine on non-small cell lung cancer. METHODS： We retrieved randomized controlled trials of efficacy of reducing phlegm with traditional Chinese medicine on non-small cell lung cancer from database of CNKI, WANFANG, VIP, PubMed that published since 2000. Three hundred and twenty-four patients treated by reducing phlegm with traditional Chinese medicine and chemotherapy were included in the experimental group; while another 323 patients treated by sole chemotherapy were included in the control group. All patients were selected then according to the including and excluding standard so as to evaluate the quality of literature. Experimental results were analyzed by STATA11.0 statistics software. RESULTS ： A total of 647 cases of non-small cell lung cancer patients were included, with 324 cases in the experimental group and 323 cases in the control group. Phlegm reducing therapy presented elevated effective rate （ RR = 1.48, 95% CI = 1.24 to 1.77, P 〈 0. 001 ） ; improved life quality （ RR = 1.92,95%CI = 1.51 to 2.45, P 〈0.001）; and better immunity （MD =0.36,95% CI = 0.23 to 0.50, P 〈 0.001 ）. CONCLUSION： Compared with conventional medicine, reducing phlegm with traditional Chinese medicine exhibit better effect on non-small cell lung cancer.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2017年第7期787-794,共8页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家中医药管理局第二批临床基地课题(JDZX2015073)
关键词
中医化痰法
非小细胞肺癌
免疫功能
生活质量
META分析
reducing phlegm with traditionalChinese medicine
non-small cell lung cancer
immunity
living quality
Meta-analysis
