摘要
目的了解新生儿百日咳毒素（pertussis toxin，PT）IgG抗体（PT-IgG）水平。方法选取2016年2月至12月在北京儿童医院顺义妇儿医院出生的419例新生儿，出生时留取脐带血2 ml，分离血清后，应用酶联免疫吸附法检测PT-IgG抗体水平。所有新生儿均门诊随访或电话跟踪随访至2017年1月31日。率的比较采用χ2检验，其他数据进行描述性分析。 结果419例新生儿的脐带血标本中，PT-IgG抗体可检测率为30.1%（126/419）。PT-IgG抗体中位数为〈5 U/ml、第90和95百分位分别为14.3和24.0 U/ml。随访截止2017年1月31日，均未发现百日咳病例。 结论2016年北京儿童医院顺义妇儿医院出生的新生儿脐带血血清百日咳抗体水平低。
ObjectiveTo investigate the levels of antibody to pertussis toxin （PT） IgG in newborns in Shunyi Women and Children＇s Hospital of Beijing Children＇s Hospital in 2016.MethodsA total of 419 newborns were enrolled in this study. Umbilical cord blood sample was collected from each subject and detected by enzyme-linked immunosorbent assay to measure the concentration of PT-IgG. Besides, all newborns were followed up to January 31, 2017. Chi-square test was used for statistical analysis.ResultsThe detectable rate of umbilical cord blood samples for PT-IgG accounted for 30.1% （126/419）. The median antibody level was 〈5 U/ml, and the 90th and the 95th percentile were 14.3 and 24.0 U/ml, respectively. No cases of pertussis occurred at the end of follow-up.ConclusionsThe newborns born in Shunyi Women and Children＇s Hospital of Beijing Children＇s Hospital are generally lack of protective PT antibody.
出处
《中华围产医学杂志》
CAS
CSCD
2017年第8期589-593,共5页
Chinese Journal of Perinatal Medicine
关键词
百白咳毒素
免疫球蛋白G
百日咳
胎血
流行病学研究
婴儿
新生
Pertussis toxin
Immunoglobulin G
Whooping cough
Fetal blood
Epidemiologic studies
Infant, newborn
