摘要
本研究旨在结合图论讨论颞叶肿瘤对整个大脑结构网络的影响以及患者认知功能变化情况.本文基于弥散张量成像技术,构建颞叶肿瘤患者以及正常对照组脑结构网络,依据纤维束连接长度,将整个脑网络分为3个子网络,对比分析各个子网络的网络参数全局效率和局部效率,进而对颞叶肿瘤患者大脑内纤维束的再生以及消亡情况做简单分析.并对两组受试者进行认知能力评估,分析患者认知能力与节点效率之间的相关性,从而得到患者大脑认知分布情况.研究结果显示,全局效率和局部效率在全脑网络结构中均无显著差异,子网络拓扑参数显示,仅在短距离子网络中,患者组较正常组有显著升高,局部参数研究结果显示,正常组均优于患者组,且患者认知能力普遍低于正常组.脑区内部纤维束再生以及不同功能区之间纤维束连接发生变化从而使得颞叶肿瘤患者脑结构网络发生重组,且患者在注意力、记忆功能、学习能力等方面较正常人有显著降低,患者额颞-顶叶部分脑区参与认知过程,特殊脑区信息处理效率的变化可间接反映认知变化情况.
This study aims to apply graph theory to investigate the influence of anatomical networks and recognition function on temporal lobe tumor patients.Diffusion tensor imaging（DTI） was utilized to construct brain anatomical networks of patients and healthy controls,then the whole brain network was divided into three sub networks on the basis of fiber length,after that,the parameters of global efficiency and local efficiency were compared and analyzed,furthermore,a simple analysis of regeneration and disappearance of fiber bundles in temporal lobe brain tumor patients was given.In addition,the cognitive assessments of two groups were examined,afterwards,the correlation between cognitive parameters and nodal efficiency were analyzed,thus we can obtain the function distribution of patients.The analysis of parameters of the whole-brain networks reveals that there is no significant difference between healthy controls and patients,besides,the parameters of controls are better than patients.The analysis of sub-networks reveals that there were significant differences only in short-range sub-networks,the global efficiency of patients is superior to healthy controls significantly.In terms of local efficiency,the healthy controls are better than patients,cognitive function of patients is lower than the normal group.We can come to the conclusion that the regeneration of fiber bundles inside the brain region and among different brain regions with long distance make the reorganization of brain function,temporal lobe tumor patients are significantly lower than healthy controls in terms of attention,memory and learning ability.The frontotemporal-parietal brain regions are involved in social cognitive function,the alteration of information processing efficiency of these special brain regions can reflect the changes of cognition indirectly.
出处
《中国科学：生命科学》
CSCD
北大核心
2017年第7期770-780,共11页
Scientia Sinica(Vitae)
关键词
颞叶
脑肿瘤
认知功能
脑结构网络
信息传输效率
temporal lobe
brain tumor
cognitive function
brain anatomical network
information processing efficiency
