摘要
磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)信号通路是一系列的级联反应过程,是一条经典的调节细胞存活、分化及凋亡信号转导通路,在生理和病理过程中起关键作用,并通过调节下游相关蛋白的活化过程发挥重要的生物学效应。由于神经细胞凋亡与一些老年性记忆减退或丧失之间有紧密联系,因此人们开始关注PI3K/Akt信号转导在神经系统发育和学习记忆中的作用机制。通过人们不断深入的研究,该信号通路在神经损伤性病变中的作用及机制被不断的发掘。总结PI3K/Akt的结构、作用机制与神经损伤性疾病中的关系,可为临床治疗神经损伤/退化性疾病提供理论指导。
Phosphoinositide-3-kinase/protein kinase B （PI3K/Akt） signal transduetion pathway is a series of cascade reaction processes and a classic signaling pathway regulating cell survival, differentiation and apoptosis. It plays a key role in the wide range of physiological and pathophysiological processes, and through the activation process of regulating downstream protein it plays an important biological effect. Because of the close relationship between neuronal apoptosis and some elderly memory degeneration or loss ,attention has been paid to the mechanism of PDK/Akt signaling in neurological development and learning memory. Through the deepgoing research, the function and mechanisms of the signal pathway are continuously explored in the nerve injury. Summary of PI3K/Akt＇s structure, mechanism and its relationship to neurotoxic diseases can provide some theoretical guidance for the clinical treatment of the nerve injury/degenerative diseases.
出处
《医学综述》
2017年第16期3121-3125,共5页
Medical Recapitulate
基金
国家自然科学基金(81560195)
内蒙古自治区自然科学基金(2015MS0864)
包头医学院科学研究基金(BYJJYF201624)
