摘要
干眼是临床最为常见的眼表疾病,其发病机制尚不清楚,建立有效的动物模型对于其机制的研究显得尤为重要。目前通过诱导动物自身免疫反应、摘除泪腺、阻断神经、使用副交感神经抑制药物等方法建立泪液生成不足型干眼动物模型;也可通过烧灼睑板腺、减少瞬目频率、喂养维生素A缺乏饲料、使用防腐剂、增加泪液渗透压、智能环境控制系统等方法建立蒸发过强型干眼动物模型;还可通过改变性激素水平、应用副交感神经抑制药物合并控制环境条件、摘除泪腺合并使用防腐剂等方法建立混合型干眼动物模型。就常见干眼动物模型作综述。
Dry eye is the most common ocular surface disease; however, its pathogenesis has not yet been fully elucida- ted. Therefore, the establishment of a dry eye model is particularly important for research into the condition＇s origins and its possible treatments. The current models used to establish tear deficiency either make use of an autoimmune reac- tion, involve the removal of the lacrimal gland （ i. e. , extirpation） or blockage of the lacrimal nerve, or use drugs that inhibit parasympathetic activity. Other methods of inducing dry eye involve burning the meibomian gland, decreasing the blink rate, reducing vitamin A intake, using preservatives, changing sex hormone levels, increasing tear osmolality, or carefully controlling the system environment. Meanwhile, some researchers combine the aforementioned models to pro- duce dry eye, including combining parasympathetic inhibitory drugs with a controlled environmental system or using pre- servatives following removal of the lacrimal gland. In this article, we summarize the commonly used dry eye models.
出处
《山东大学耳鼻喉眼学报》
CAS
2017年第4期109-113,共5页
Journal of Otolaryngology and Ophthalmology of Shandong University
基金
国家自然科学基金(81574028)
