摘要
目的探讨谷草转氨酶(AST)与代谢综合征(MS)及其相关因素之间的关联,为代谢综合征的早期预防诊断提供科学依据。方法选取北京小汤山医院体检中心连续参加2012年1月~2015年12月体检者为研究对象,采用Pearson方法研究基线AST与终点MS组分之间的相关性,并将研究对象按照基线AST四分位数法分四组(AST 1~4组,即AST最低到最高组),运用广义估计方程分析随基线AST水平升高MS发病风险的变化规律。结果本研究共纳入2003名男性,平均年龄(45.52±14.33)岁;2050名女性,平均年龄(42.39±11.72)岁。MS 4年发病率为0.94%。基线AST水平[(19.24±0.12)U/L]明显低于2015年终点水平[(20.99±0.15)U/L],差异有统计学意义(P<0.05)。Pearson相关分析和控制年龄及MS其他组分后的偏相关分析显示,AST与空腹血糖、三酰甘油呈正相关关系(P<0.01)。广义估计方程分析显示,在调整了年龄、性别后,AST的升高与MS发病风险的增加呈正相关(OR=1.00793,95%CI:1.00351~1.01236,P=0.00043)。结论 AST与MS及其组分存在相关性,可作为MS发病的一个预测指标。
Objective To explore the association of aspartate transaminase （AST） with metabolic syndrome （MS） and its components, in order to provide scientific basis for the early diagnosis of MS. Methods Individuals taken continuous physical examination in Physical Examination Center of Beijing Xiaotangshan Hospital from January 2012 to December 2015 were recruited in the study. Pearson correlation was used to analyze the correlation of baseline AST with MS and its components. The subjects were divided into four groups according to the baseline AST quartile （AST 1-4, from AST lowest to highest）. Generalized estimation equation was applied for data analysis. Results There were 2003 males, aver- age of （45.52±14.33） years old; and 2050 females, average age of （42.39±11.72） years old. The incidence of MS was 0.94% in the four years. The average baseline （2012 year） AST level [（19.24±0.12） U/L] was significantly lower than individu als in 2015 [（20.99±0.15） U/L], with statistically significant difference （P 〈 0.05）. Pearson analysis and adjustment of age and other components of MS showed that there were positive correlations between AST and FPG, TG （P 〈 0.01）. Gener- alized estimation equation revealed that increased AST was positively correlated to the higher risk of MS after age and sex being adjusted （OR=1.00793, 95%Ch1.00351-1.01236, P=0.00043）. Conclusion AsT is closely correlated with MS and its components, and it can be used as a predictor of MS.
出处
《中国医药导报》
CAS
2017年第23期114-117,共4页
China Medical Herald
关键词
谷草转氨酶
代谢综合征
肥胖
血压
血脂
Aspartate aminotransferase
Metabolic syndrome
Obesity
Blood pressure
Lipids
