摘要
目的探讨血清补体C3、C4与原发性高血压及其危险因素同型半胱氨酸(HCY)和血脂的关系。方法选取20例健康体检者为对照组,45例高血压患者为高血压组。高血压组依据血脂异常防治指南又分为调脂组和未调脂组,分别测定各组血清补体C3、C4和HCY、总胆固醇、低密度脂蛋白、载脂蛋白等水平,并采用Pearson相关性分析补体与HCY及血脂指标的相关性。结果与对照组比较,高血压组的补体C3、C4显著升高,差异有统计学意义(P<0.05),HCY亦显著升高(P<0.05)。高血压组Pearson相关性分析显示,补体C3与总胆固醇、低密度脂蛋白、载脂蛋白B均呈正相关(P<0.05);补体C3、C4与同型半胱氨酸无关(P=0.073,P=0.699)。与未调脂组比较,调脂组补体C4、总胆固醇、低密度脂蛋白、载脂蛋白B显著降低(P<0.05)。调脂组Pearson相关性分析显示,补体C3、C4与低密度脂蛋白等血脂指标无关(P>0.05);补体C3、C4与同型半胱氨酸无关(P=0.074,P=0.894)。结论补体C3、C4与原发性高血压密切相关;补体系统激活是高血压重要危险因素;调脂治疗明显减轻高血压患者的免疫损伤;高同型半胱氨酸血症(HHCY)是原发性高血压独立危险因素。
Objective To investigate the relationship of complements C3 and C4 with essential hypertension and its risk factors, homocysteine （HCY） and blood lipids. Methods We selected 20 healthy subjects for physical checkup as control group and 45 patients with hypertension as hypertension group. According to The Guidelines for Prevention and Treatment of Dyslipidemia in Chinese Adults, the hypertension group was divided into lipid regulating therapy group and non-lipid regulating therapy group. We determined the levels of complements C3 and C4, HCY, total cholesterol, low density lipoprotein and apolipoprotein. Pearson linear correlation regression analysis was used to analyze the correlation of the complements with HCY and blood lipid indexes. Results Complements C3 and C4 were significantly higher in the hypertension group than in the control group （P〈0.05）. HCY was also significantly higher than that in control group （P〈0.05）. The Pearson linear correlation analysis showed that in the hypertension group Complement C3 was positively correlated with cholesterol, low density lipoprotein and apolipoprotein B （P〈0.05）. Complements C3 and C4 were not related to HCY （P = 0. 073, P = 0.699）. Compared with the non-lipid regulating therapy group, C4, cholesterol, low density lipoprotein and apolipoprotein B were significantly decreased in the lipid regulating therapy group （P〈0.05）. The Pearson linear correlation analysis showed that in the lipid regulating therapy group complements C3 and C4 were not related to low density lipoprotein （P〈0.05） or to homocysteine （P=0.074, P=0.894）. Oonclusion Complements C3 and C4 are closely related to essential hypertension. Activation of the complement system is one of the important risk factors for hypertension. The lipid regulating therapy can significantly alleviate immune damage in patients with essential hypertension. Hyperhomocysteinemia is an independent risk factor for essential hypertension.
作者
倪宁
翁改志
刘庆安
王东琦
NI Ning WENG Gai-zhi LIU Qing an WANG Dong-qi(Department of Medicine, Hospital of Xi＇an Jiaotong University, Xi＇an 710049 Department of Cardiology, the First Affiliated Hospital of Xi＇an Jiaotong University, Xi＇an 710061, China)
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2017年第5期702-705,共4页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
西安市科技计划项目[No.SF09026(1)]~~
关键词
补体
原发性高血压
同型半胱氨酸
总胆固醇
低密度脂蛋白
载脂蛋白
complement
essential hypertension
homocysteine
total cholesterol
low density lipoprotein
apolipoprotein
