摘要
1-epi-Castanospermine（5） was synthesized from readily available 2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin（11） in 9 steps and 21% overall yield, with selective debenzylation, Barbier reaction and reductive amination as the main reaction steps.
1-epi-Castanospermine（5） was synthesized from readily available 2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin（11） in 9 steps and 21% overall yield, with selective debenzylation, Barbier reaction and reductive amination as the main reaction steps.
基金
Financial support from the National Natural Science Foundation of China(No.21272240)
National Science and Technology Major Projects for“Major New Drugs Innovation and Development”(No.2013ZX09508104)
National Engineering Research Center for Carbohydrate Synthesis of Jiangxi Normal University
