摘要
目的探讨熊去氧胆酸胶囊联合地塞米松磷酸钠注射液治疗老年肝内胆汁淤积性肝炎的临床疗效。方法选取2014年12月—2016年12月重庆市大足区人民医院收治的老年肝内胆汁淤积性肝炎患者70例,按随机数字法将所有患者分为对照组和治疗组,每组各35例。对照组口服熊去氧胆酸胶囊,1粒/次,3次/d;治疗组在对照组的基础上静脉滴注地塞米松磷酸钠注射液,5 mg加入到10%葡萄糖500 m L中,1次/d。两组连续治疗2周。观察两组的临床疗效,比较两组的肝功能和生活质量评分情况。结果治疗后,对照组和治疗组的总有效率分别为71.43%、94.29%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组总胆汁酸(TBA)、直接胆红素(DBIL)、天冬氨酸氨基转氨酶(AST)和丙氨酸氨基转移酶(ALT)均显著下降,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组腹部症状、全身症状、乏力、活动、焦虑和情感功能评分均显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显高于对照组,两组比较差异具有统计学意义(P<0.05)。结论熊去氧胆酸胶囊联合地塞米松磷酸钠注射液治疗老年肝内胆汁淤积性肝炎具有较好的临床效果,可改善肝功能,提高生活质量,安全性较好,具有一定的临床推广应用价值。
Objective To investigate the effect of Ursodeoxycholic Acid Capsules combined with Dexamethasone Sodium Phosphate Injection in treatment of senile intrahepatic cholestasis hepatitis. Methods Elderly patients（70 cases） with intrahepatic cholestasis hepatitis in Chongqing Dazu District People＇s Hospital from December 2014 to December 2016 were randomly divided into control and treatment groups, and each group had 35 cases. Patients in the control group were po administered with Ursodeoxycholic Acid Capsules, 1 grain/time, three times daily. Patients in the treatment group were iv administered with Dexamethasone Sodium Phosphate Injection on the basis of the control group, 5 mg added into 10% glucose solution 500 m L, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and liver function and quality of life scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 71.43% and 94.29%, respectively, and there was difference between two groups（P〈0.05）. After treatment, TBA, DBIL, AST, and ALT in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, the scores of abdominal symptoms, systemic symptoms, weakness, movement, anxiety, and emotional function in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Ursodeoxycholic Acid Capsules combined with Dexamethasone Sodium Phosphate Injection has clinical curative effect in treatment of senile intrahepatic cholestasis hepatit
作者
夏红
孙明玉
XIA Hong SUN Ming-yu(Department of Infectious Diseases, Chongqing Dazu District People＇s Hospital, Chongqing 402360, Chin)
出处
《现代药物与临床》
CAS
2017年第7期1285-1288,共4页
Drugs & Clinic
关键词
熊去氧胆酸胶囊
地塞米松磷酸钠注射液
肝内胆汁淤积性肝炎
肝功能
生活质量评分
Ursodeoxycholic Acid Capsules
Dexamethasone Sodium Phosphate Injection
intrahepatic cholestasis hepatitis
liver function
quality of life score
