摘要
目的探讨结肠软斑病的临床病理特征、诊断与鉴别诊断及治疗与预后。方法分析1例结肠软斑病的临床表现及病理学特征,并复习相关文献。结果本例临床表现及肠镜结果疑为结肠癌,活检组织检查见大片组织细胞样细胞,细胞质丰富,局部细胞内外可见特征性呈靶环状或枭眼样的Michaelis-Gutmann小体,PAS和普鲁士蓝铁染色(+)。免疫组化:组织细胞样细胞CD68和CD163弥漫(+)。结论结肠软斑病比较少见,依据临床表现及肠镜结果容易误诊为肿瘤,熟悉并掌握其病理特征是诊断的关键。
Objective To explore the clinical pathological features,diagnosis differential diagnosis and prognosis of colonic malakoplakia. Methods The clinical manifestation and pathological features were analyzed in one case of colonic malakoplakia with review of relevant literatures. Results The case was misdiagnosed as colon cancer by the analysis of clinical manifestation and colonoscopy. The histologic examination of the biopsy specimen revealed sheets of histiocytes containing abundant eosinophihc cytoplasm. Outsides of histiocytoid cells,we found Michaelis-Gutmann bodies（ M-G bodies）,which look like ＂owl-eye cell＂or ＂targetoid appearance cell＂. And they were positive with Prussian blue（ for iron） and periodic acid-Schiff staining. Immunohistochemically, histiocytes were positive for CD68 and CD163.Conclusion Colonic malakoplakia is a rare disease,which is frequently misdiagnosed as a malignant disease because of the clinical manifestation and colonoscopy findings. Correct pathologic diagnosis may play an important role in standard treatment and prognostic evaluation of colonic malakoplakia.
作者
李秋雨
刘琼雯
孙松
李惠翔
LI Qiu-yu LIU Qiong-wen SUN Song LI Hui-xiang(Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Chin)
出处
《诊断病理学杂志》
2017年第7期521-523,共3页
Chinese Journal of Diagnostic Pathology
关键词
结肠软斑病
M-G小体
特殊染色
免疫组化
Colonic malakoplakia
Michaelis-Gutmann bodies
Specific staining
Immunohistochemistry
