摘要
目的研究不同剂量硫唑嘌呤(AZA)治疗难治性溃疡性结肠炎(RUC)对激素撤停的影响。方法纳入80例RUC患者作为研究对象,随机分为低剂量组和高剂量组,每组各40例。两组分别给予口服AZA1.5 mg/kg/d和3 mg/kg/d,两组均同时联合醋酸泼尼松激素治疗,激素撤离后维持AZA干预。比较两组治疗效果及不良反应发生情况,采用线性回归分析法探讨不同治疗剂量AZA对患者激素撤停的影响。结果两组治疗效果无显著性差异(P>0.05)。低剂量组治疗后不良反应总发生率为10%,高剂量组为30%,组间比较,差异有统计学意义(P<0.05)。AZA治疗剂量与患者激素撤停时间呈显著正相关性(r=0.9086)。结论口服1.5 mg/kg/d和口服3 mg/kg/d剂量的AZA治疗RUC效果相当,但1.5 mg/kg/d能显著缩短激素治疗时间,从而减少不良反应,安全性更好。
Objective To study the effect of different doses of azathioprine on hormone withdrawalin the treatment of refractory ulcerativecolitis（RUC）.Methods Eighty patients with RUC were randomly assigned tolow dose group and high dose group,with 40 cases in each group. The two groups were treated with oral AZA by 1.5 mg/kg/d and 3 mg/kg/d,respectively,in addition to hormone therapy.Azathioprine was maintained after hormone withdrawal. The treatment effects and adverse reactions were compared,and the effect of different doses on hormone withdrawal was analyzed by multiple linear regression analysis. Results The treatment effects showed no significant difference between the two groups（P〉0. 05）.The incidence of adverse reactions in the low-dose group after treatment was10%,while in the high dose group 30%（P〈0. 05）.The dose of azathioprine was significantly positively correlated with the time ofhormone withdrawal（r = 0.9086）.Conclusion The effects of oral 1.5 mg/kg/d and oral 3 mg/kg/d dose of azathioprineare similar in the treatment of RUC,but 1.5 mg/kg/d of azathioprine significantly shortened the duration of hormone therapy,reduces adverse reaction,with better safety.
作者
熊清平
王善飞
张天翔
Xiong Qingping Wang Shanfei Zhang Tianxiang.(Department of Gastroenterology,Luzhou People＇s Hospital of Sichuan Province, Luzhou, Sichuan, 646000, Chin)
出处
《结直肠肛门外科》
2017年第3期348-351,共4页
Journal of Colorectal & Anal Surgery
