摘要
慢加急性肝衰竭(acute-on-chronic liver failure,ACLF)是以慢性肝病基础上发生的急性肝功能失代偿和短期高死亡率为主要临床特征的一种可逆的、复杂的临床综合征.由于不同区域ACLF的病因不同,且病理机制复杂,导致东西方对ACLF的定义及诊断标准仍存在争议,且缺乏公认的预后评估体系.近年来,ACLF引起了国内外学者的广泛关注,取得了一些重要的研究进展,本文将围绕国际上ACLF的最新进展,对ACLF的定义及预后评估等进行分析总结.
Acute-on-chronic liver failure（ACLF） refers to a complex clinical syndrome with fast progression and high mortality. There is discrepancy between the East and West in the definition and diagnostic criteria for ACLF, and no uniform prognostic evaluation system is currently applicable, because of the different causes and the complexity of pathogenesis. In recent years, ACLF has attracted attention of scholars all over t he world, and some important progress has been made. This paper aims to make a summary of ACLF with regard to its definition and the prognostic evaluation system.
作者
王宪波
高方媛
Xian-Bo Wang Fang-Yuan Gao(Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China)
出处
《世界华人消化杂志》
CAS
2017年第21期1910-1920,共11页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.81473641
北京市医院管理局临床医学发展专项基金资助项目
No.ZYLX201707~~
关键词
慢加急性肝衰竭
定义
预后
Acute-on-chronic liver failure
Definition
Prognosis
