摘要
目的探究临床治疗冠心病慢性心力衰竭中阿托伐他汀的最佳用药剂量。方法随机选择我院90例因患有冠心病慢性心衰于2015年8月至2017年1月接受入院专业治疗的患者,均用药阿托伐他汀,且依据不同剂量标准分为A组(44例)用药剂量为20.0 mg,B组(46例)剂量为40.0 mg,统计分析两组患者的临床效果及各临床指征改善情况。结果 A组患者的治疗总效率为77.27%,B组患者的治疗总有效率为95.65%;A组患者的治疗总有效率低于B组(χ~2=6.5742,P<0.05)。此外,两组患者用药期间均未出现任何不良反应。用药前,两组患者的6 min步行距离、LVEF、LVESD及LVEDD比较,无显著差异(P>0.05);用药后,两组患者的上述各项指标均显著改善,且B组各项指标均优于A组(P<0.05)。结论冠心病患者并发慢性心衰症状采用阿托伐他汀治疗时,剂量为40.0mg效果更突出,推荐临床应用。
Objective To explore the optimal dose of atorvastatin in the clinical treatment of coronary heart disease complicated with chronic congestive heart failure. Methods A total of 90 cases of patients with coronary heart disease complicated with chronic congestive heart failure accepting professional admission treatment in our hospital from August 2015 to January 2017 were randomly selected, all the patients accepted atorvastatin treatment. And they were divided into group A （44 cases） with the dosage of 20.0 mg and group B （46 cases） with the dosage of 40.0 mg. The clinical effects and improvements of clinical indications were recorded and analyzed in the two groups. Results The total effective rate was 77.67% in the group A, and 95.65% in the group B; the total effective rate in the group A was lower than that in the group B （χ2=6.5742, P〈0.05）. In addition, there was no adverse reactions appeared in the two groups during the medication. Before drug use, there were no significant differences in the 6 min walking distance, LVEF, LVESD and LVEDD between the two groups （P〉0.05）. After drug use, the above indexes in the two groups significantly improved, those in the group B were better than the group A （P〈0.05）. Conclusion When patients with coronary heart disease complicated with chronic congestive heart failure treated with atorvastatin, the effect is more prominent with the dose of 40.0 mg, which is recommended for clinical application.
作者
黄金稳
HUANG Jin-wen(People＇s Hospital of Shanyang County, Shangluo 726400, Chin)
出处
《临床医学研究与实践》
2017年第22期63-64,共2页
Clinical Research and Practice
关键词
冠心病慢性心衰
阿托伐他汀
用药剂量
coronary heart disease complicated chronic with congestive heart failure
atorvastatin
dosage
