摘要
目的:探讨经肝动脉化疗栓塞术(TACE)治疗对原发性肝癌患者凝血功能、肝功能及肝纤维化指标的影响。方法:118例原发性肝癌患者作为观察组,100例健康体检者作为对照组。观察组患者经TACE治疗一周后,比较对照组与观察组治疗前后凝血功能(APTT、PT及FIB)、肝功能(TBIL、DBIL、IBIL、ALB及ALT)及肝纤维指标(LN、HA、PⅢP及ⅣC)等水平。结果:观察组治疗后的APTT、PT水平均显著高于组内治疗前,且均显著低于对照组,差异有统计学意义(P<0.05),观察组治疗后FIB水平显著低于治疗前,且明显高于对照组,差异比较有显著性(P<0.05);与观察组治疗前相比,治疗后的TBIL、DBIL、IBIL、ALT水平均显著升高,ALB水平显著降低,且观察组治疗前后的TBIL、DBIL、IBIL、ALT水平均显著高于、ALB显著低于对照组,差异比较有显著性(P<0.05);观察组治疗前后的LN、HA、PⅢP及ⅣC水平均显著高于对照组,且治疗后LN、HA、PⅢP及ⅣC水平均显著高于治疗前,差异比较有显著性(P<0.05)。结论:TACE治疗原发性肝癌可有效改善患者的凝血功能,化疗药物及栓塞治疗过程可损伤患者的肝细胞,对患者的肝功能及肝纤维化指标有一定的影响。
Objective：To explore effect of transcatheter arterial chemoembolization（TACE）on coagulation function,liver function and liver fibrosis index in patients with primary liver cancer.Methods：118cases of patients with primary liver cancer as observation group and 100 cases of persons with health check-up as control group.After treatment for one week with TACE,compared coagulation function（APTT,PT and FIB）,liver function（TBIL,DBIL,IBIL,ALB and ALT）and liver fibrosis indexes（LN,HA,PⅢP andⅣC）in control group and observation group before and after treatment.Results：Levels of APTT,PT in observation group after treatment were higher than before treatment in group,moreover were lower than the control group,there was statistical significant difference（P〈0.05）,level of FIB after treatment in observation group was significantly lower than before treatment and obviously higher than control group,difference was significant（P〈0.05）;Compared with observation group before treatment,levels of TBIL,DBIL,IBIL,ALT increased dramatically,ALB level decreased obviously after treatment,moreover levels of TBIL,DBIL,IBIL,ALT in observation group before and after treatment were significant higher and ALB level was lower than that in control group,difference was significant（P〈0.05）;levels of LN,HA,PⅢP andⅣC in observation group before and after treatment exceeded significantly in control group,levels of LN,HA,PⅢP and ⅣC after treatment was higher when compared with before treatment,the difference comparison was statistical significant（P〈0.05）.Conclusions：It could effectively improve coagulation function through treating primary liver cancer patients with TACE,however,chemotherapy drug and embolotherapy would damage liver cells of patients and affect the liver function and liver fibrosis at some extent.
作者
马美雪
孙西龙
郭永高
纪龙
MA Mei-xue SUN Xi-long GUO Yong-gao JI Long(Department of Gastroenterology, Xuzhou Central Hospital, Xuzhou City, Jiangsu Province, 221009, China)
出处
《海南医学院学报》
CAS
2017年第12期1705-1708,共4页
Journal of Hainan Medical University
基金
江苏省科技支撑计划(BG2016299)~~
关键词
原发性肝癌
TACE
凝血功能
肝功能
肝纤维化指标
Primary liver cancer
TACE
Coagulation function
Liver function
Liver fibrosis index
