摘要
替考拉宁是临床用于治疗耐甲氧西林金葡菌(MRSA)感染的重要药物之一,但其疗效和安全性受多种因素的影响,如老年重症感染、儿童、肾功能受损、低蛋白血症等,因此对特殊患者应用替考拉宁进行治疗药物监测(TDM)并以此调整给药方式显得尤为重要。对低蛋白血症患者,除了监测总药物谷浓度外,监测游离药物谷浓度也很有必要。
Teicoplanin is one of glycopeptide antibiotics used to treat meticillin resistant Staphylococcus aureus （MRSA） infections, and its efficacy and safety are impacted by many factors, such as severe infection, children, renal dysfunction, hy- poalbuminaemia, etc. So for the special patients, it is most important to monitor therapeutic drug concentrations and adjust drug administration. In addition to monitoring the total trough concentrations, it is necessary to monitor free trough concentra- tions in patients with hypoalbuminaemia.
出处
《中国医院药学杂志》
CAS
北大核心
2017年第15期1536-1539,共4页
Chinese Journal of Hospital Pharmacy
关键词
替考拉宁
治疗药物监测
低蛋白血症
游离药物谷浓度
teicoplanin
therapeutic drug monitoring
hypoatbuminaemia
free trough concentration
