摘要
非酒精性脂肪肝炎(NASH)是一种代谢综合性肝病,是在肝脏细胞脂肪变性基础上进一步诱发炎性反应及纤维化。枯否细胞(KCs)是一种肝巨噬细胞,NASH进展过程中,KCs能够在脂质、内毒素、氧化应激等刺激作用下分泌炎性因子,引发肝细胞炎性反应,损伤肝脏。该文就KCs激活分泌的炎症因子在NASH发病机制中的作用进行详细论述。
Non-alcoholic steatohepatitis （NASH） is a metabolic syndrome hepatopathy and on the basis of hepatic cells steatosis,it fur-ther induces inflammatory response and hepatic fibrosis. Kupffer cells （ KCs） are hepatic macrophages, which in the development of NASH secret inflammatory cytokines in the stimulus action of lipid metabolism, endotoxin, oxidative stress and so forth. They can induce inflammatory response of hepatic cells and injure the liver. This paper reviews in detail how the inflammatory cytokines secreted by KCs function in NASH pathogenesis.
出处
《安徽医药》
CAS
2017年第9期1583-1585,共3页
Anhui Medical and Pharmaceutical Journal
基金
武汉市卫计委科研项目(WZ15C05)
关键词
非酒精性脂肪肝炎
枯否细胞
炎症因子
Nonalcoholic steatohepatitis
Kupffer cells
Inflammatory cytokines
