摘要
氢气以往被视为惰性气体,只应用于潜水医学,并未受到其他医学学科重视。自从2007年,日本学者发现氢气可以有效地清除自由基,改善大脑的缺血再灌注损伤,自此改变了人们的认知。此后,各国科学家积极开展各种实验以研究氢气的效应。目前,氢气被证实的效应有抗氧化、抗炎、抗凋亡等,有数十种疾病模型和人类疾病用氢气治疗有效,但其治疗疾病的具体机制尚不明确。神经损伤是一种既有药物较难治愈且起效缓慢的疾病,其损伤机制包括过氧化损伤和炎症反应等,目前临床并没有有效的解决办法。越来越多的实验人员将目光转移到氢气生物学效应研究,建立了各类中枢神经损伤或者外周神经损伤模型,用于探讨氢气对神经损伤的保护作用及机制研究。目前,氢气或氢水治疗已应用于多种神经损伤模型,并被证实有保护效应,其中包括大脑的外伤性脑损伤、缺血缺氧损伤、出血后损伤和脊髓的打击伤、钳夹伤、缺血再灌注损伤、外周神经缺损损伤、视神经损伤以及自身免疫性脑脊髓炎等。本文就氢气在神经损伤保护中的研究进展作一综述。
Hydrogen was considered as an inert gas and had been used in diving medicine only,and had not been valued in other medical disciplines. Since 2007, the Japanese scholars have found that hydrogen can effectively remove free radi- cals and prevent the cerebral ischemia reperfusion injury, which begins to change the people＇ s cognition. Since then, sci- entists have actively carried out various experiments to study the effect of hydrogen. At present, the effect of hydrogen is confirmed to be antioxidant, anti-inflammatory, anti apoptosis and so on. Dozens of disease models and human diseases with hydrogen therapy are effective, but the mechanism of treatment is not clear. Nerve injury is a kind of disease which is difficult to be cured and has a slow onset. The injury mechanism of nerve injury includes oxidative damage and inflamma- tory reaction. There is no effective solution to treat it. The researchers are giving more and more attention to the research on the biological effects of hydrogen and investigate the protective effect on nerve injury. There are a variety of nerve injury model proved to be effective by hydrogen or hydrogen water treatment. At present, hydrogen or hydrogen water treatment has been applied to a variety of nerve injury model, including traumatic brain injury, brain ischemia and hypoxia injury, bleeding and spinal cord blow injury, clamp injury,ischemia-reperfusion injury, peripheral nerve defect injury, optic nerve injury and autoimmune encephalomyelitis. In this paper,the research progress of hydrogen in the protection of nerve injury is reviewed.
作者
张哲
叶斌
马辉
ZHANG Zhe YE Bin MA Hui(Department of Rehabilitation Medicine and Physical Therapy ,Bengbu Medical College ,Bengbu ,Anhui 233000, Chin)
出处
《中华全科医学》
2017年第10期1768-1772,共5页
Chinese Journal of General Practice
关键词
氢气
中枢神经
外周神经
抗氧化
抗炎
Hydrogen
Nervous centralis
Peripheral nervous
Antioxidant
Anti-inflammatory
