摘要
目的探讨不影响宫腔形态的肌壁间子宫肌瘤对体外受精-胚胎移植(IVF-ET)妊娠结局的影响及随访观察。方法选取于生殖中心行IVF-ET,不孕合并超声检查示不影响宫腔形态的肌壁间子宫肌瘤患者91例,共行胚胎移植100个周期(观察组),抽取同期行IVF-ET治疗的单纯输卵管性不孕不合并子宫肌瘤患者100例(对照组)。对两组的一般情况、控制性超排卵情况、体外受精参数和妊娠结局进行回顾性对照分析。结果两组的基本情况差异无统计学意义。观察组与对照组的胚胎种植率(26.7%vs 30.5%)、临床妊娠率(48.0%vs51.0%)、自然流产率(20.8%vs 31.4%)、活产率(32.0%vs 28.0%)、早产率(9.4%vs 7.1%)差异无统计学意义(P>0.05)。随访示观察组和对照组的剖宫产率为81.3%(26/32)和71.4%(20/28),差异无统计学意义(P>0.05)。观察组剖宫产术中行肌瘤剔除者超过半数(11/20),剔除的肌瘤大小为2~5 cm,无出现术中大出血。结论不影响宫腔形态的肌壁间子宫肌瘤对IVF-ET临床妊娠结局无明显不良影响。
Objective To evaluate the effect of uterine non - cavity - distorting intramural fibroids on the outcome of IVF. Methods A retrospective study on patients undergoing IVF - ET in the reproductive medicine center was conducted. 91 women with intramural fibroids and 100 women free of fibroids were included. All patients underwent sonography to rule out intra - cavity lesions. We compared the basic characteristics and main IVF - ET outcomes between the two groups. Results There was no significant difference between the two groups in basic characteristics. There was no significant difference between study and control groups in implantation rate （26. 7% vs. 30. 5% ） , clinical pregnancy rate （48.0% vs. 51.0% ）, spontaneous abortion rate （20. 8% vs. 31.4% ）, live birth rate （32.0% vs. 28.0% ）, or premature birth rate（9.4% vs. 7. 1% ）. The follow -up results demonstrated that patients in the study group had higher cesarean section rate （81.3% vs. 71.4% ） , but with no statistical significance. More than half of the patients with cae- sarean section underwent cesarean myomeetomy. The intramural fibroids were 2 to 5 cm in diameter. No major hemorrhage during cesarean myomectomy was reported. Conclusion Non - cavity - distorting intramural fibroids have no effect on the outcome of IVF.
作者
戴凯玲
李瑞岐
方庭枫
王良岸
黎颖
王文军
DAI Kai -ling LI Rui - qi FANG Ting -feng WANG Liang - an LI Ying WANG Wen -jun.(Reproductive center, Sun Yat - sen Memorial Hospital of Sun Yat - sen university, Guangzhou 510120, Guangdong, China)
出处
《广东医学》
CAS
北大核心
2017年第15期2308-2311,共4页
Guangdong Medical Journal
基金
广东省公益研究与能力建设专项资金项目(编号:2014A020213014)
广东省自然科学基金项目(编号:2015A030313086)
广东省医学科研基金立项项目(编号:A2015143)
