摘要
硫肽类抗生素是一类富含硫元素且被高度修饰的聚噻(噁)唑多肽类天然产物,该家族化合物以其复杂的分子结构、良好的生物活性以及新颖的抗菌作用模式而成为研究热点.近年来,对于硫肽类抗生素类似物的合成研究发展迅速.综述了通过化学半合成、组合生物合成以及前体导向突变生物合成方法获得的硫肽类抗生素类似物的研究进展.
Thiopeptide antibiotics, which are a growing class of sulfur-rich and highly modified polyazolyl peptide natural products, have been appreciated because of their complex structures, potent biological activities and unusual modes of action. Recently, a great deal of effort has been devoted to the development of various approaches for the efficient synthesis of thiopeptide antibiotics analogues. This review summarizes synthetic approaches towards thiopeptide antibiotics analogues via semisynthesis, combinatorial biosynthesis and precursor-directed mutasynthesis.
作者
王守锋
郑庆飞
段盼盼
刘文
Wang Shoufeng Zheng Qingfei Duan Panpan Liu Wen(College of Chemistry and Chemical Engineering,University of dinan, Jinan 250022 Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, University of dinan, dinah 250022 State Key Laboratory of BioOrganic and Naturai Products Chemistry, Shanghai Institute of Organic Chemistry,Chinese Academy of Science, Shanghai 200032)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2017年第7期1653-1666,共14页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.31430005)
山东省自然科学基金(No.ZR2016HM44)资助项目~~
