摘要
目的探讨新辅助化疗联合肿瘤细胞减灭术及术后腹腔热灌注治疗晚期卵巢癌的近、远期疗效，并为晚期卵巢癌的临床治疗提供依据。方法选择2014年1月～2015年12月经我院妇科临床检查、问诊及影像学检测拟定的卵巢癌患者72例做为观察对象，将患者分成新辅助化疗联合CDS及术后IHCP组（观察组）和常规CDS及术后卡铂州顷铂化疗组（对照组），每组各36例。对两组患者的手术情况、术后并发症和临床疗效等进行定期临床随访与比较分析。结果观察组的手术时间、腹水量、失血量和化疗疗程显著低于对照组，差异具有统计学意义（t=2．944，P=0．018；t=3．320，P=0．004；t=3．651，P=0．026；t=3．704，P=0．012）。观察组术后1个月、3个月和1年内两组患者的总复发率显著低于对照组，差异有统计学意义（χ^2=2．886，P=0．022;χ^2=3．461，P=0．018;χ^2=3．552，P=0．015）。术后1个月、3个月和1年观察组的盆腹部的疼痛率均显著低于对照组，差异有统计学意义（r=3．221，P=0．028；χ^2=3．430，P=0．014;χ^2=3．384，P=0．009）。术后1个月、3个月及1年观察组的总有效率均显著高于对照组，差异有统计学意义（χ^2=2．655，P=0．023;χ^2=3．022，P=0．031;χ^2=3．461，P=0．018）。结论新辅助化疗联合CDS及术后IHCP方法对于晚期卵巢癌均具有较好的临床疗效，近期与远期的综合疗效均优于传统的化疗技术。具有快速、有效、并发症少及安全性好的临床效果，具有较高的临床应用价值。
Objective To investigate the immediate and long - term curative effect of the neoadjuvant chemotherapy com- bined with cytoreductive surgery （CDS） and postoperative intraperitoneal hyperthemic chemoperfusion （IHCP） in the patients with advanced ovarian cancer and to provide the basis of treatment of the advanced ovarian cancer. Methods 72 Patients with the advanced ovarian cancer in our hospital from January in 2014 to December in 2015 were enrolled. They were randomly divided into the neoadjuvant chemotherapy combined with CDS and postoperative IHCP group （observation group, n = 36 ） and the conventional CDS and postoperative carboplatin/cisplatin chemotherapy group （ control group, n = 36 ）. The surgery, postoperative complications and the clinical curative effect in the two groups were compared and analyzed. Results The operation time, volume of ascites, bleeding volume and chemotherapy regimen in the observation group were significantly lower than those in the control group. There were statistically significant difference （ t = 2.944,P = 0. 018;t = 3. 320,P = 0. 004;t = 3. 651 ,P = 0. 026;t = 3. 704,P = 0. 012 ）. The recurrence rate on the 1 month, 3 months and 1 year after the surgery in the observation group were significantly lower than that in the control group. There was statistically significant difference （χ^2= 2. 886 ,P = 0. 022 ;χ^2= 3.461 ,P = 0. 018 ;χ^2= 3. 552 ,P = 0. 015 ）. The basin and abdominal pain rates on the 1 month, 3 months and 1 year after the surgery in the observation group were significantly lower than those in the control group. There were statistically significant difference （ χ^2 = 3. 221 ,P = 0. 028 ;χ^22 = 3. 430 ,P = 0. 014;χ^2 = 3. 384,P = 0. 009 ）. The total effective rate on the 1 month, 3 months and 1 year after the surgery in the observation group was significantly higher than that in the control group. There were statistically significant difference （ χ^2 = 2. 655 ,P = 0. 023 ; χ^2=3. 022,P = 0. 031 ;χ^2 = 3. 461 ,P = 0. 018 ）. Co
出处
《国际老年医学杂志》
2017年第4期145-148,154,共5页
International Journal of Geriatrics
基金
国家自然科学基金资助项目（81571736）
关键词
新辅助化疗
肿瘤细胞减灭术
腹腔热灌注
晚期卵巢癌
疗效
Neoadjuvant chemotherapy
Cytoreductive surgery
Intraperitioneal hyperthermic chemoperfuson
Advanced ovarian cancer
Curative effect
