摘要
国际癌症研究机构（IARC）工作组最近在回顾了流行病学数据、动物研究结果以及机制研究数据后得出结论：过量的身体脂肪会增加结直肠、肝、胆囊、胰腺、肾脏、甲状腺、乳腺（绝经后）、子宫内膜、卵巢、食管（腺癌）、胃贲门的癌症风险，还会导致神经瘤以及多发性骨髓瘤的发生’。这可能使多余的身体脂肪成为继使用烟草之后第二个重要的可控制的癌症危险因素。
The association is now clear; it’s time to get serious about preventionThe International Agency for Research on Cancer (IARC) working group recently reviewed epidemiological data, studies in experimental animals, and mechanistic data and concluded that excess body fatness causes cancer of the colon and rectum, liver, gallbladder, pancreas, kidney, thyroid, breast (postmenopausal), endometrium, ovary, oesophagus (adenocarcinoma), and gastric cardia, as well as meningioma and multiple myeloma.1 This potentially makes excess body fat the second most important modifiable cancer risk factor after tobacco use.The study by Kyrgiou and colleagues2 took up the challenge of evaluating the robustness of multiple, sometimes overlapping, meta-analyses that reported an association between body adiposity measures (such as body mass index, weight gain, and waist circumference) and cancer. The authors conducted an umbrella review, also known as a “review of reviews” or “meta-review,”34 and initially identified a total of 204 individual meta-analyses from 49 papers. They further examined the 95 meta-analyses that reported the association between body fatness measured on a continuous scale (mostly body …
出处
《英国医学杂志中文版》
2017年第7期361-362,共2页
The BMJ Chinese Edition
