摘要
目的:比较不同温度下不同浓度的普鲁卡因和布比卡因对牛蛙坐骨神经动作电位的影响。方法:将72只牛蛙共解剖出144根坐骨神经,随机分为3组,每组各48根,Ⅰ组药物温度18℃,Ⅱ组药物温度25℃,Ⅲ组药物温度35℃,每组分为四个亚组,分别用1%和0.5%浓度的普鲁卡因和布比卡因对坐骨神经进行阻断,并采用多道生理信号记录仪采集神经动作电位,比较不同条件下药物对神经的阻滞时间以及在去掉药物后神经的再现时间。结果:相同温度相同浓度下,普鲁卡因与布比卡因相比较,麻醉起效稍慢,而去掉药物后的再现时间较短。对于同一阻滞剂来说,相同温度下,1%的比0.5%的阻滞起效快,且再现时间长;相同浓度下,Ⅰ组18℃时,阻滞起效时间最长,Ⅱ组25℃处于中间,Ⅲ组35℃,药物阻滞起效时间最短,但再现时间无显著差异。结论:药物温度和药物浓度对阻滞剂的起效时间都有影响,同浓度的布比卡因的阻滞时间明显短于普鲁卡因,且阻滞持续时间长。
Objective： To compare the effects of procaine and bupivacaine under different temperature and different concentration on the excitability of the bullfrog sciatic nerve. Methods： 144 sciatic nerve from 72 bullfrog were dissected and randomly divided into 3 groups with 48 nerves in each group. The temperature of the drug is 18℃ for Group I, 25℃ for Group II, and 35℃ for Group III. Each group was divided into 4 sub-group. 1% and 0.5% procaine and bupivacaine were used to block the sciatic nerve for each sub-group, respectively. The action potential was recorded by a multi-channel physiological signal recorder. The onset time and recorvery time of the drug under different conditions were compared. Results： In the condition of same temperature and same concentration, the onset time of Procaine was significantly slower than that of bupivacaine. However, the recorvery time of Procain after removing the drug was much shorter than that ofbupivacaine. For the same drug, the onset time of 1% concentration was faster than 0.5% at the same temperature and the recorvery time of 1% was longer than that of 0.5%. The onset time was also affected by the temperature. The onset time was reduced with the increase of the temperature. But the recovery time was not affected by the temperature. Conclusion： Both temperature and concenlration could affect the oneset of the local anesthetics. Bupivacaine has shorter oneset time and longer recovery time than procaine at the same concentration.
出处
《中国疼痛医学杂志》
CAS
CSCD
2017年第7期502-506,共5页
Chinese Journal of Pain Medicine
基金
国家自然科学基金青年科学基金项目(31500796)
关键词
温度
普鲁卡因
布比卡因
动作电位
坐骨神经
Temperature
Procaine
Bupivacaine
Action potential
Sciatic nerve
