摘要
线粒体是细胞中最为重要的细胞器之一,通过氧化磷酸化产生ATP维持细胞正常生理功能,还参与钙离子稳态、细胞凋亡和类固醇激素合成等生物学过程。此外,线粒体是唯一含有功能性基因组(mtDNA)的细胞器。精子作为高度分化的生殖细胞,其线粒体与其他细胞存在许多异同之处。由于精子的特殊性,精子中线粒体的功能以及mtDNA是否遗传给子代方面的研究已成为关注的焦点。本文综述了精子线粒体和mtDNA的生物学特征、功能以及受精后的去向。
Mitochondria play important role in oxidative phosphorylation, calcium homeostasis, apoptosis, and steroidogenesis. Moreover, mitochondria is the only organelle that contains its own functional genome. Sperm is a highly differentiated gamete. Although the mitochondria in the sperm share many common features with those in other somatic cells, they show some unique characteristics. To date, the role of mitochondria in sperm and its final fate are still controversial. Here, we review the current understanding of the mitochondria and their mtDNA, including the biological characteristics, the functions, and the fate after fertilization.
作者
贺斌
郭会朵
赵茹茜
He Bin Guo Huiduo Zhao Ruqian(KeyLaboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China)
出处
《石河子大学学报（自然科学版）》
CAS
2017年第2期133-138,共6页
Journal of Shihezi University(Natural Science)
基金
国家重点研发计划项目(2016YFD0500502)
国家自然科学基金项目(31502027)
关键词
精子
线粒体
MTDNA
母系遗传
sperm
mitochondria
mitochondrial DNA （mtDNA）
maternal inheritance
