摘要
目的探讨干扰素-γ（IFN-γ）联合黄芪注射液治疗病毒性心肌炎（VMC）的临床效果。方法选择2013年2月至2016年10月于东莞市第八人民医院与南方医科大学珠江医院住院治疗确诊为VMC的患者82例，按照数字表法随机分为对照组与观察组，各41例。对照组给予维生素C、辅酶Q10、ATP、肌酐等，采取抗病毒、极化液及其他对症常规治疗；观察组则在对照组基础上给予IFN-γ联合黄芪注射液治疗，疗程3周；比较两组临床疗效。结果观察组总有效率为95．12％，明显高于对照组的78．05％（χ^2=5．1447，P〈0．05）．两组治疗后血清炎症因子TNF-α和IL-6水平均较治疗前明显降低（均P〈0．05），观察组治疗后TNF-α和IL-6水平较对照组降低更加显著（t=-3．7799、-3．0881，均P〈0．05）。结论IFN-γ联合黄芪注射液治疗VMC疗效确切、安全、可靠，缩短病程，不良反应少，值得临床大力推广应用。
Objective To investigate the clinical effect of interferon-γ（IFN-γ） combined with astragalus injection in the treatment of viral myocarditis （VMC）. Methods 82 patients hospitalized with VMC were randomly divided into a control group and an observation group using digital table method, 41 for each group. The control group were given vitamin C, coenzyme Q10, ATP, creatinine, etc. and took antiviral treatment, polarized solution, and other symptomatic conventional treatment; in addition, the observation group were given IFN-γ and astragalus injection for 3 weeks. The clinical efficacies were compared between these groups. Results The total effective rate was 95.12% in the observation group and was 78.05% in the control group （χ^2=5.144 7, P 〈 0.05）. The levels of TNF-γ and IL-6 were significantly lower after than before the treatment in both groups （both P 〈 0.05）. The levels of TNF-α and IL-6 were significantly lower in the observation group than in the control group after the treatment （t=-3.779 9, -3.088 1, both P 〈 0.05）. Conclusions IFN-γ combined with astragalus injection in the treatment of VMC is effective, safe, and reliable and can shorten the disease course and reduce adverse reactions, so it is worth being clinically generalized.
出处
《国际医药卫生导报》
2017年第15期2359-2362,共4页
International Medicine and Health Guidance News
基金
东莞科技局课题（2016108101029）
