摘要
目的:探讨伴单侧外周前庭受损(UPVD)的头晕/眩晕患者的病因学、临床特征及相关危险因素。方法:连续收集我院神经科门诊就诊的伴UPVD的头晕/眩晕患者148例为病例组,同期收集我院健康体检门诊年龄、性别相匹配的187例健康人为对照组。收集2组研究对象的基线资料,分析伴UPVD的头晕/眩晕患者的病因及伴发疾病分布,应用多元Logistic回归分析伴UPVD的头晕/眩晕患者的独立危险因素。结果:148例伴UPVD的头晕/眩晕患者年龄9~86岁,男:女约为1:2。可以头晕(74.3%)或眩晕(25.7%)起病,分原发性(23.0%)和继发性/伴发性(77.0%)。原发性伴UPVD的头晕/眩晕患者包括急性原发单侧前庭病、发作性原发单侧前庭病、慢性原发单侧前庭病;继发/伴发性伴UPVD的头晕/眩晕患者包括良性阵发性位置性眩晕、持续性姿势-感知性头晕、可能的迷路卒中、慢性缺血性单侧前庭病可能、内耳缺血性发作性前庭病变可能、前庭性偏头痛、梅尼埃病、前庭神经元炎及迷路震荡。多元Logistic回归分析提示高血压、高脂血症是伴UPVD的头晕/眩晕患者的独立危险因素(P<0.05)。结论:神经科门诊伴UPVD的头晕/眩晕患者常伴有动脉粥样硬化危险因素。病因诊断较为困难,病因不明最为多见,其次多因伴发良性阵发性位置性眩晕、持续性姿势-感知性头晕和可能的迷路卒中而就诊。
Objective： To explore the etiology, clinical manifestations and relative risk factors of dizziness/vertigo in patients with unilateral peripheral vestibular dysfunction （UPVD）. Methods： One hundred and forty-eight dizziness/vertigo patients with UPVD （UPVD group） and 187 healthy controls （control group） were en- rolled. The clinical data of 2 groups were collected and analyzed. Multivariate logistic regression analysis was used to analyze the independent risk factors for dizziness/vertigo patients with UPVD. Results： Cases in UPVD group aged from 9 to 86 years, and female/male ratio was 2/1.74.3% of the cases in UPVD presented dizziness and 25.7% presented vertigo. 23.0% of them were primary UPVD and 77.0% were secondary/concomitant UP- VD. The causes for patients with primary UPVD included acute primary UPVD, episodic primary UPVD and chronic primary UPVD. The causes for patients with secondary/concomitant UPVD included benign paroxysmal positional vertigo, persistent postural-perceptual dizziness, possible labyrinthine apoplexy, possible chronic isch- emic UPVD, possible inner ear ischemic episodic vestibular disorder, vestibular migraine, meniere disease, ves- tibular neuritis and labyrinthine, concussion. Multivariate logistic regression analysis showed that hypertension and hyperlipidemia （P〈0.05） were independent risk factors for dizziness/vertigo patients with UPVD. Conclu- sion： Dizziness/vertigo patients with UPVD are often accompanied by atherosclerosis risk factors. It is difficult to make a etiological diagnosis. Most of them are found to be associated with benign paroxysmal positional verti- go, persistent postural-perceptual dizziness and possible labyrinthine apoplexy.
作者
凌霞
白晋
张欢
申博
杨旭
LING Xia BAI Jin ZHANG Huan SHEN Bo YANG Xu(Peking Uni- versity Aerospace Clinical College of Medicine, Beijing 100049, China Department of Neurology, Aerospace Center Hospital, Peking University Aerospace Clinical College of Medicine, Beijing 100049, China The Grad- uate Student Training Base-AeroSpace Center Hospital of Liaoning Medical University Beijing 100049, China)
出处
《神经损伤与功能重建》
2017年第4期316-318,共3页
Neural Injury and Functional Reconstruction
基金
院级课题资助(No.YN201305)
关键词
单侧外周前庭受损
病因
危险因素
unilateral peripheral vestibular dysfunction
etiology
risk factors
