摘要
基于短暂性脑缺血发作的中医、西医临床病症特点,对目前现有的短暂性脑缺血发作模型进行总结归纳,通过整理分析短暂性脑缺血发作各个动物模型的优缺点、中西医诊断标准以及临床症状吻合度,进一步提出相应动物模型的评价思路及改进方法。而且还发现短暂性脑缺血发作动物模型虽然造模方法比较多,但不能很好地反映该病的短暂性、可逆性、反复发作性等典型特征,与临床病症特点差异较大,且缺少对该动物模型造模成功与否的合理的量化标准。通过利用现有的单因素动物模型相结合,建立与临床病症相结合的、更接近人类短暂性脑缺血发作典型症状的复合动物模型,复制出能更加吻合临床病症特点的动物模型。建立合理的模型量化标准,体现其中西医病因,完善一套系统完整的模型评价方法,是短暂性脑缺血发作动物模型未来的发展方向。
Based on the clinical symptom characteristics of transient ischemic attack in Chinese and Western medicines, the exist- ing models of transient ischemic attack were summarized and analyzed. Then the advantages and disadvantages of each model, the diag- nostic criteria of traditional Chinese and Western medicine and clinical symptoms compliance were analyzed to put forward the evalua- tion method and improvement method of the corresponding animal models. It was found that there were many modeling methods of tran- sient ischemic attack, but they can not reflect the transience, reversibility, recurrence and other typical characteristics of the disease, with significant differences with clinical symptoms. Moreover, there is lack of reasonable quantitative criteria for the success of the ani- mal model. By combining the existing single factor animal models, a composite animal model that was more closely related to the clini- cal symptoms of transient ischemic attack was established to replicate an animal model that was more compatible with the characteristics of clinical symptoms. It is the future development directions of the transient ischemic attack animal models to establish reasonable quan- titative standards, reflect the causes of Chinese and Western medicine symptoms and improving a series of systematic and complete model evaluation methods.
作者
项丽玲
苗明三
王灿
张梦飞
方晓艳
XIANG Li-iing MIAO Ming-san WANG Can ZHANG Meng-fei FANG Xiao-yan(Henan University of Chinese Medicine, Zhengzhou 450046, Chin)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2017年第14期2824-2828,共5页
China Journal of Chinese Materia Medica
基金
国家"重大新药创制"科技重大专项(2009ZX09103-324)
国家自然科学基金项目(U1204827)
河南省优秀科技创新团队(TCJ2014-391)
