摘要
人类辅助生殖技术给我国日益增长的不孕不育患者带来了希望,但同时也增加了后代出生缺陷甚至成人疾病的发生风险。本文阐述了影响优生的配子、胚胎、母源因素以及辅助生殖安全性,旨在强调提升下一代健康水平应以配子/胚胎健康为本,可借助基因组学新技术降低遗传性出生缺陷发生率,防控胚胎发育源性成年病风险。
Human assisted reproductive technology has brought hope to the growing infertility population,but also has increased the risk of birth defects and even adult disease incidence.Here we discussed the gametes,embryos and maternal factors which affect eugenics and assisted reproductive safety.With the help of the new genomics technology such as the next generation sequencing,we can greatly reduce the incidence of hereditary birth defects,and prevent and control embryonic developmental risk of adult diseases.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2017年第7期832-835,共4页
Academic Journal of Second Military Medical University
基金
国家科技部重大研究计划(2007CB948101
2012CB944903
2014CB964903)~~
关键词
辅助生殖技术
先天畸形
基因组学
表观遗传
assisted reproductive techniques
congenital abnormalities
genomics
epigenetics
