摘要
【目的】探讨网织红细胞（RET）计数动态监测对乳腺癌化疗致骨髓抑制的评估价值。【方法】110倒乳腺癌患者均接受化疗治疗，1疗程21d，干预1～4疗程，通过全自动血细胞分析仪对各疗程化疗前、化疗后1周、2周、3周网织红细胞百分比（RET％）、高荧光强度网织红细胞百分率（HFR）、中荧光强度网织红细胞百分率（MFR）进行测定。【结果】与化疗前比较，第1～4疗程化疗后1周、2周RET％、HFR均显著降低，且差异有显著性（P〈0．05）；第1～3疗程化疗后3周RET％、HFR、MFR与化疗前比较差异无显著性（P〉0．05）；第3～4疗程化疗后2周MFR与化疗前比较差异无显著性（P〉0．05）；第4疗程化疗后3周HFR明显低于化疗前（P〈0．05）。【结论】乳腺癌化疗不同疗程期间行RET相关指标动态监测对骨髓抑制、开始恢复情况评估具有重要作用。
[Objective]To explore the value of dynamic monitoring of reticulocyte count in the evaluation of bone marrow suppression induced by chemotherapy on breast cancer. [Methods]One hundred and ten patients with breast cancer received chemotherapy. 21d was a course of treatment, and the patients were intervened for 1- 4 courses. The automatic blood cell analyzer was used to determine the percentages of reticulocyte, high fluorescencereticulocyte （HFR） and moderate fluorescencereticulocyte （MFR） before each course of chemotherapy, at 1 week, 2 weeks and 3 weeks after chemotherapy. [Results] Compared with those before chemotherapy, RET~ and HFR at 1 week and 2 weeks after the 1~ 4th course of hcemotherapy were significantly lower, and the difference was significant （ P %0.05） ~ At 3 weeks alter the 1~~~ 3~a course of hcemotherapy, there were no significant differences in RET%, HFR and MFR, compared with those before chemotherapy （ P i〉0.05）;There were no significant differences in MFR at 2 weeks after the 3- 4^th course of chemotherapy, compared with that before chemotherapy （ P 〉0.05）; At 3 weeks after the 4th course of chemotherapy, HFR was significantly lower than that before chemotherapy （ P 〈0.05）. [Conclusion]The dynamic monitoring of reticulocyte related indexes during different periods of chemotherapy of breast cancer plays an important role in the evaluation of bone marrow suppression and recovery.
出处
《医学临床研究》
CAS
2017年第7期1256-1257,1260,共3页
Journal of Clinical Research
