摘要
目的观察解毒活血配方颗粒冲服对经皮冠状动脉介入术(PCI)患者的围术期心肌损伤的影响。方法 160例接受PCI术的心绞痛患者随机分为解毒活血组(n=84)和对照组(n=76),解毒活血组给予常规治疗同时术前第7天给予解毒活血配方颗粒冲服,每日1剂。对照组给予基础药物治疗。测定PCI术前及术后12 h、24 h的血清肌酸激酶同工酶(CK-MB)和肌钙蛋白I(cTn I)浓度。结果解毒活血组PCI术后12 h、24 h cTn I和CK-MB水平均显著低于对照组(P=0.0038,P=0.027 6;P=0.001 2,P=0.002 7)。解毒活血组患者术后cTn I和CK-MB升高大于正常值3倍者构成比均显著低于对照组(P=0.008 2,P=0.007 6)。结论术前给予解毒活血配方颗粒对于PCI围手术期病人的心肌损伤具有一定的保护作用。
Objective To observe the influence of Jiedu Huoxue Fang （Detoxification and Blood- Activating Granules） on perioperative myocardial injury in patients undergone percutaneous coronary intervention （PCI）. Methods The patients with angina pectoris received PCI （n = 160） were randomly divided into Jiedu Huoxue Fang group （n = 84 ） and control group （n = 76 ）. The Jiedu Huoxue Fang group was given routine treatment and Jiedu Huoxue Fang （1 dose/d） 7 d before PCI. The control group was treated with basic drugs. The levels of serum creatine kinase-M B isoenzyme （CK-MB） and cardiac troponin I （cTn I） were detected before and 12 h and 24 h after PCI. Results The levels of serum cTn I and CK-MB were significantly lower in Jiedu Huoxue Fang group than those in control group 12 h after PCI （P =0. 003 8, P =0.027 6） and 24 h after PCI （P =0. 001 2, P =0. 002 7）. The constituent ratio of patients with cTn I and CK-MB increasing by 3 times more than normal value was significantly lower in Jiedu Huoxue Fang group than that in control group （ P = 0. 008 2, P = 0. 007 6 ）. Conclusion Jiedu Huoxue Fang administrated before PCI has a certain preventive effect on perioperative myocardial damage.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2017年第7期603-606,共4页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(No.81403386)
江苏省自然科学基金资助项目(No.BK20161078)
中国中医科学院江苏分院资助项目(No.JSBY1316)~~
关键词
解毒活血
经皮冠状动脉介入术
围术期心肌损伤
detoxification and blood-activating
percutaneous coronary intervention
perioperative myocardial damage
