摘要
目的探讨持续正压通气（CPAP）对合并OSAHS的2型糖尿病患者动态血糖、胰岛素抵抗等作用。方法采用电脑生成随机序列方法将符合纳入排除标准的77例受试者分成两组，即实验组（常规降糖治疗＋CPAP）和对照组（常规降糖治疗），对比干预前及干预3d、1个月、3个月、6个月、12个月的空腹血糖、空腹胰岛素水平、餐后2h血糖、糖化血红蛋白、胰岛素抵抗指数、24h内平均血糖、日平均血糖、夜间平均血糖、日间血糖波动幅度（MAGE）及夜间MAGE。结果对照组中，干预后3d、1个月、3个月、6个月、12个月各时间段与干预前相比较，上述指标的改善差异均无统计学意义（P〉0．05）。实验组中，与干预前相比较，干预后3d上述指标的改变差异无统计学意义（P〉0．05），干预1个月后空腹血糖、夜间MAGE的改善差异有统计学意义（P〈0．05），干预3个月、6个月、12个月后，动态血糖、胰岛素抵抗等改善差异均有统计学意义（P〈0．05）。与干预后1个月相比较，干预3个月后夜间平均血糖、日问MAGE的改善差异有统计学意义（P〈0．05）；干预6个月、12个月后胰岛素抵抗指数、24h内平均血糖、夜间平均血糖、日间MAGE、夜间MAGE的改善差异有统计学意义（P〈0．05）。结论CPAP干预可显著改善合并2型糖尿病的0sAHS患者动态血糖、胰岛素抵抗水平，且干预时间越长，疗效越明显。
Objective To investigating the effects of dynamic glucose and insulin resistance of continuous positive airway pressure （CPAP） to the obstructive sleep apnea hypopnea syndrome （OSAHS） in patients with type 2 diabetes. Methods 77 patients meeting the inclusion and exclusion criteria were using computer generated random sequence method divided into two groups, the experimental group （routine hypoglyeemic treatment ＋ CPAP） and the control group （routine hypoglycemic treatment）. Contrast before intervention and intervention for 3 days, 1 month, 3 months, 6 months, 12 month of fasting plasma glucose, insulin levels, 2 hours blood sugar after meal, glycosylated hemoglobin, insulin resistance index, the average daily average blood sugar, blood sugar, 24 h average blood sugar, blood sugar fluctuation in the day and night blood glucose fluctuation. Results In the control group, intervention after 3 days, 1 month, 3 months, 6 months, 12 months each time compared with before intervention, improved the above indicators had no statistical significance （ P ^- 0.05）. In the experimental group, compared with before intervention, the index change had no statistical significance intervention after 3 days （ P 〉0.05）, fasting blood glucose, blood sugar mean ambulatory glucose excursions （MAGE） at night to improve was statistically significant intervention after 1 month （ P 〈 0.05）, dynamic blood sugar, insulin resistance,such as improving had statistical significance intervention after 3 months, 6 months and 12 month （ P〈 0.05）. Compared with 1 month after the intervention, the improvement of average blood sugar and blood sugar fluctuation in the day after were statistically significant in the intervention after 3 months （ P 〈-~, 0.05）. The insulin resistance index, the average blood glucose within 24 h. the average blood glucose, blood sugar fluctuation in the day, night improved blood sugar fluctuation was statistically different in intervention after 6 months and 12 month （ P �
出处
《国际呼吸杂志》
2017年第13期993-998,共6页
International Journal of Respiration
基金
广东省清远市科技计划项目（20158033）
