摘要
目的:探讨阿托伐他汀对老年冠心病合并糖尿病患者的治疗效果及对血脂、尿酸水平的影响。方法:收集我院就诊的116例冠心病合并糖尿病患者,随机分为对照组和实验组,每组各58例。两组患者入院后均给予控制血糖、降血压等对症治疗。对照组患者给予阿司匹林肠溶片0.3~0.6g/次,3次/d,口服,氯吡格雷片2片/次,1次/d,口服,硝酸甘油0.25~0.5 g/次,3次/d,含服;实验组患者在对照组基础上给予阿托伐他汀片10~20 mg/次,1次/d,治疗连续4周,治疗期间根据患者情况及时调整药量。观察并比较两组患者治疗前后血清低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、总胆固醇(TC)、尿酸(UA)、糖化血红蛋白(HbA1c)水平以及临床疗效。结果:与治疗前相比,两组患者治疗后的血清LDL-C、TG、TC、UA、Hb A1c水平均下降,HDL-C水平升高,差异具有统计学意义(P<0.05);与对照组相比,实验组患者的LDL-C、TG、TC、UA、Hb A1c水平较低,HDL-C水平及临床治疗有效率均较高,差异均具有统计学意义(P<0.05)。结论:阿托伐他汀能够有效降低老年冠心病合并糖尿病患者血糖、血脂以及尿酸水平,且临床治疗效果较好。
Objective： To investigate the effect of atorvastatin on the blood lipid and uric acid levels of eldedy patients with coronary heart disease complicated with diabetes mellitus. Methods： 116 patients with coronary heart disease and diabetes were randomly divided into the control group and the experimental group, 58 cases in each group. Both groups of patients were given blood glucose control, blood pressure and other symptomatic treatment. The control group was treated with Aspirin Enteric-coated Tablets 0.3-0.6 g/times, 3 times/d, oral, clopidogrel tablets, 2 tablets each time, 1 time/d, oral, nitroglycerin, 0.25-0.5 g/time, 3 times/d, with service; the experimental group was given atorvastatin on the basis of control group, 10-20 mg/time, 1 time/d, treatment for 4 weeks. During the treatment, the dosage was timely adjusted according to the conditions of patients. The serum low density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C）, triglyceride （TG）, total cholesterol （TC）, uric acid （UA）, glycosylated hemoglobin （HbAlc） levels before and after treatment and the clinical treatment efficiency were observed and compared between two groups. Results： Compared with before treatment, the serum LDL-C, TG, TC, UA, HbAlc levels were decreased after treatment in both groups of patients, the HDL-C level was increased （P〈0.05）; compared with the control group, the serum LDL-C, TG, TC, UA, HbAlc levels were lower, HDL-C level was higher in the experimental group （P〈0.05）; compared with the control group, the effective rate of clinical treatment of the experimental group were higher （P〈0.05）. Conclusion： Atorvastatin could effectively reduce the blood glucose, blood lipid, uric acid levels of elderly patients with coronary heart disease complicated with diabetes.
出处
《现代生物医学进展》
CAS
2017年第23期4564-4567,共4页
Progress in Modern Biomedicine
基金
陕西省教育厅专项基金项目(16JK1667)
西安医学院校级重点建设学科基金项目(16JK1667)
关键词
阿托伐他汀
冠心病
糖尿病
血脂
尿酸
Atorvastatin
Coronary heart disease
Diabetes mellitus
Blood lipids
Uric acid
