摘要
本文对40例急性心肌梗塞患者血浆组织型纤溶酶原激活剂(tPA)含量,活性及纤溶酶原激活剂抑制物(PAI)活性进行测定。结果显示,发病时患者血浆tPA含量、PAI活性分别显著高于对照组(P<0.01),而tPA活性明显低于对照组(P<0.01),65岁以上老年患者的上述指标的异常变化尤为显著,对可能的机制进行了讨论。
Plasma levels of tissue plasminogen activator (tPA) tPA activity and plasminogen activator inhibitor (PAI) activity were determined in 40 cases of acute myocardial infarction (AMI) at the onset and 2 weeks after the onset of the disea se. Twenty four healthy subjects served as control. At the onset of AMI, mean plasma level of tPA was significantly higher than that of controis (13.5±4.8 ng/ml vs 6.4±2.0 ng/ml) with highest elevation in the group>65 years of age. Mean plasma level of tPA activity was significantly lower than controls (1.1±0.4 IU/ml vs 1.6±0.4 IU/ml) especially in patients>65 years of age. Mean plasma level of PAI activity was significantly higher than con trols (17.5±12.0 AU/ml vs 9.0±4.6 AU/ml) especially in patienls>65 years of age. After 2 weeks, mean plasma levels of tPA activity end PAI activity of AMI patients returned to 1.5±0.6 IU/ml and 9.5±8.9 AU/ml respectively, not significantly different from controls. While tPA concentration decreased to 11.0±5.4 ng/ml hut still higher than controls. The possible mechanism of these phenomena was discussed.
出处
《中国循环杂志》
CSCD
1991年第3期202-204,共3页
Chinese Circulation Journal
关键词
心肌梗塞
TPA
PAI
血浆
老年人
Acute myocardial infarction
Tissue plasminogen activator
Plasminogen activator inhibitor
