摘要
目的:了解溃疡性结肠炎患者凝血功能和C反应蛋白的改变及其意义。方法:收集2009年9月～2011年10月本院治疗的溃疡性结肠炎患者80例及100例健康对照者的血浆,进行D-二聚体、部分凝血活酶时间、纤维蛋白原和C反应蛋白定量检测。结果:溃疡性结肠炎患者血浆D-二聚体、纤维蛋白原和C反应蛋白水平显著高于健康对照组(P<0.01),而部分凝血活酶时间则显著低于健康对照组(P<0.01)。结论:溃疡性结肠炎患者血液内存在高凝状态,持续的高凝状态可能与其临床进展有关。D-二聚体、纤维蛋白原和C反应蛋白测定可作为判断溃疡性结肠炎患者病情严重程度的有效指标,对疾病的诊断和预后判断有重要的指导价值。
Objective To Study the clinical significance of the changes of clotting function and C-reactive protein levels in patients with ulcerative colitis.Methods From September 2009 to October 2011,80 ulcerative colitis patients and 100 healthy controls were collected.D-Dimer(DD),activated partial thromboplastin time(APTT),fibrinolysis(FIB) and C-reactive protein(CRP) were detected.Results DD,FIB and CRP were makeedly higer in patients with ulcerative colitis than those in control group(P<0.01),but APTT was lower(P<0.01).Conclusion The ulcerative colitis patients are in hypercoagulation states,Persistent hypercoagulation may contribute to the clinical course of the ulcerative colitis.Plasma DD,FIB and CRP could be effective indicators for the judgement of the severity of ulcerative colitis and have certain instructive value in the diagnosis and prognosis of disases.
出处
《湖南师范大学学报（医学版）》
2012年第2期91-93,共3页
Journal of Hunan Normal University(Medical Sciences)
